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UnknowntsRNA-00764 Regulates Estrogen and Progesterone Synthesis and Lipid Deposition by Targeting PPAR-γ in Duck Granulosa Cells.
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S-EPMC11508606 | biostudies-literature
ProteomicsMining novel gene targets for improving tolerance to furfural and acetic acid in Yarrowia lipolytica using whole-genome clustered regularly interspaced short palindromic repeats interference library
In this study, a whole-genome CRISPRi library was developed in Y. lipolytica and applied for enforcing the tolerance to furfural and acetic acid. Several novel gene targets were discovered through NGS before and after screening. And to analyze the tolerance mechanism caused by transcriptional repres...
ORGANISM(S): Yarrowia Lipolytica 
2024-03-31 | PXD051116 |
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
ProteomicsGenome-wide targets identification for high-titer production of free fatty acids in Escherichia coli
We employed omics analyses to identify potential targets in multiple cellular processes, enabling systematical discovery of beneficial chromosomal gene targets that can be engineered to optimize free fatty acids (FFAs) production in Escherichia coli.
ORGANISM(S): Escherichia Coli 
2020-06-03 | PXD017890 |
ProteomicsCharacterization of lysine acetylome in mice subjected to chronic intermittent hypoxia
Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in ...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049226 |
ProteomicsChanges in the hippocampal proteome of chronic intermittent hypoxia mice
Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hip...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049225 |
ProteomicsGenome-scale CRISPRi screen identifies pcnB repression conferring overproduction of free fatty acids in Escherichia coli
In this study, we carried out genome-scale CRISPRi modulation combining fluorescence-activated cell sorting (FACS) and next-generation sequencing (NGS) to identify genetic determinants for FFAs overproduction in Escherichia coli. The pcnBi (AP) strain that repressed the expression of pcnB produced 2...
ORGANISM(S): Escherichia Coli 
2024-05-18 | PXD052390 |
ProteomicsAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
ProteomicsProteomics data of colorectal cancer
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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