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MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
ProteomicsTranslational and Post-translational LC-MS of Naïve and Primed hESCs
Deciphering the regulatory network for human naïve and primed pluripotency is of fundamental theoretical and applicable significance. Here, by combining quantitative proteomics, phosphoproteomics and acetylproteomics analyses, we revealed RNA processing and translation as the most differentially-reg...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD030230 | Pride
Lc-ms Primed Human Hesc Naïve 
ProteomicsComparative phosphoproteomic analyses of OCT4 protein in hESC
This study is directed to systematically map out phosphorylation sites in OCT4 protein that are differentially phosphorylated between naïve hESCs and their primed counterparts, and to further identify the upstream kinases that phosphorylate the sites in naïve hESC-specific manner
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033619 | Pride
Human Lc-ms/ms Hesc 
ProteomicsEndogenous OCT4 interactome in hESC
In two widely-cited OCT4-protein interactome papers, Ding et al. (Ding et al., 2012) used murine ESC nuclear extract to identify OCT4 interactome in nucleus and Pardo et al. (Pardo et al., 2010) used whole cell lysate to identify OCT4 interactome in murine ESCs. In both papers, Benzonase, a genetica...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033840 | Pride
Oct4 Esc Human 
Transcriptomicsm6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
N6-methyladenosine (m6A) has been recently identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms, and functions in cell reprogramming are largely unknown. Here, we report m6A modification profiles in the mRNA transcriptomes of four cell...
ORGANISM(S): Mus musculus 
2015-03-10 | E-GEOD-52125 | biostudies-arrayexpress
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
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