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ProteomicsFumarate hydratase suppresses glioblastoma progression via a TRIM17-RRN3 proteostatic axis
Emerging evidence indicates that metabolic reprogramming plays a pivotal role in glioblastoma (GBM) progression. Here, we report that the expression of fumarate hydratase (FH) is significantly reduced in GBM patient samples. FH overexpression suppresses the viability, migration, and invasion of GBM ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067085 | Pride
Human Succination U87 Gbm Lc-ms/ms 
ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
UnknownWild rice GL12 synergistically improves grain length and salt tolerance in cultivated rice.
Not available
S-EPMC11530696 | biostudies-literature
ProteomicsComparative Phosphoproteomics Reveals a Role for AMPK in Hypoxia Signaling in Testes of Oriental River Prawn (Macrobrachium nipponense)
Hypoxia is one of the major stresses in aquaculture animals. Recently, we reported that hypoxia disrupts the endocrine system and inhibits testicular function of oriental river prawns (Macrobrachium nipponense), but the molecular mechanism of testes responded to hypoxia remains largely unknown. In t...
ORGANISM(S): Macrobrachium Nipponense 
2021-03-09 | PXD024614 |
ProteomicsSirtuin 5-mediated desuccinylation of ALDH2 alleviates mitochondrial oxidative stress following acetaminophen-induced acute liver injury
WT mice and SIRT5 knockout mice were injected with APAP by intraperitoneal injection, and liver tissue specimens were taken 24 hours later for protein succinylation modification histology analysis
ORGANISM(S): Mus Musculus 
2024-02-24 | PXD050121 |
ProteomicsProteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue.
Proteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue from Wilms tumor patients.
ORGANISM(S): Homo Sapiens 
PXD063650 |
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
PXD021722 |
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
PXD045174 |
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