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ProteomicsChem-CRISPR/dCas9FCPF - A platform for chemically induced epigenome editing
Epigenetic aberration is one of the major driving factors in human cancer, often leading to acquired resistance to chemotherapies. Various chemical epigenetic modulators have been reported. Nonetheless, outcomes from animal models and clinical trials have underscored the substantial setbacks attribu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048673 | Pride
Chemical epigenetic modulators Crispr/dcas9 Gene therapy Epigenome editing 
ProteomicsProteomics analysis of a new Cas9-targeting PROTAC molecule
Scientists have developed several methods to control the activity of Cas protein in a timely way and hence reduce off-target effects, including anti-CRISPR proteins and small molecule inhibitors. The PROTAC is a new conception of using the natural ubiquitin-proteasome system to degrade the protein o...
ORGANISM(S): Homo sapiens (Human) 
2022-10-18 | PXD022199 | Pride
Crispr-cas9 Qexactive hf Protac Lc-ms/ms 
ProteomicsA PROTAC Targets Splicing Factor 3B1
The proteolysis-targeting chimera (PROTAC) is a new technology to degrade a target protein. However, its clinical application is limited currently by lack of chemical binders to target protein. For instance, it is still unknown, whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-08 | PXD024661 | Pride
Hela Tmtpro Protac Orbitrap lumos 
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