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ProteomicsProteomics to determine metallodrug targets and optimal drug combinations
The FITExP profiling approach was used to identify protein hits from cells incubated with RAPTA-T or RAPTA-EA. Validation experiments with paclitaxel and cisplatin underlined the reliability of the method and hit lists for both test compounds (and?) gave physiologically viable anti-cancer mechanisms...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD005766 | Pride
Drug targets Fitexp Cancer 
ProteomicsDeMix:efficient identification of co-fragmented peptides
A data analysis workflow with a simple deconvolution method based on high resolution data-dependent tandem mass spectrometry.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080702 | MassIVE
ProteomicsTowards a species search engine: KISSE offers a rigorous statistical framework for bone collagen tandem mass spectrometry data
DNA and bone collagen are two key sources of resilient molecular markers used to identify species from their remains. Collagen is more stable than DNA, and thus it is preferred for ancient and degraded samples. Current mass spectrometry-based collagen sequencing approaches are empirical and lack a r...
ORGANISM(S): Ziphius cavirostris Physeter Cygnus cygnus Hydrodamalis gigas Ursus maritimus (Polar bear) (Thalarctos maritimus) Phoca vitulina Ursus arctos (Brown bear) (Grizzly bear) Mirounga leonina Eschrichtius robustus Halichoerus grypus Balaena mysticetus Rangifer tarandus (Reindeer) (Cervus tarandus) Falco peregrinus 
2025-11-10 | PXD060919 | Pride
Collagen Lc-ms/ms Species identification 
ProteomicsAnticancer effect of deuterium depleted water - comprehensive proteomics analysis suggests a redox disbalance mechanism
The proteomics data is derived from 4 parts of samples prepared and analysed by nanoLC-MS/MS. In order to make appropriate statistical analysed could be performed, all treatments were performed in biological replicates. The number of replicates was 4 for protein abundances analysis (part 1), 2 for t...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011085 | Pride
Anticancer Proteomics Redox disbalance Deuterium depleted water 
ProteomicsCysteine alkylating methods in shotgun proteomics and their possible effects on methionine residues
Neatly every proteomic protocol has a Cysteine reduction and alkylation step in it preceding the trypsin digestion. It needs to be done in order to remove the s-s bonds and prevent proteins from folding, thus, provide better access for trypsin. Among various reagents used for alkylation, iodoacetami...
ORGANISM(S): Homo sapiens (Human) 
2020-10-28 | PXD013973 | Pride
Cysteine Proteomics Alkylation Methionine 
ProteomicsCysteine alkylating methods in shotgun proteomics and their possible effects on methionine residues
Neatly every proteomic protocol has a Cysteine reduction and alkylation step in it preceding the trypsin digestion. It needs to be done in order to remove the s-s bonds and prevent proteins from folding, thus, provide better access for trypsin. Among various reagents used for alkylation, iodoacetami...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD015889 | Pride
Cysteine Proteomics Alkylation Methionine Reduction 
UnknownHow well can morphology assess cell death modality? A proteomics study.
Not available
S-EPMC5045961 | biostudies-literature
UnknownToward a Species Search Engine: KISSE Offers a Rigorous Statistical Framework for Bone Collagen Tandem Mass Spectrometry Data.
Not available
S-EPMC12561455 | biostudies-literature
ProteomicsProTargetMiner: A proteome library of anticancer molecules for functional discovery
As a further development of our Functional Identification of drug Targets by Expression Proteomics (FITExP) method, a reference dataset was built of the proteomic responses of A549 human adenocarcinoma cells to 56 clinical and experimental anticancer molecules. For each molecule, a concentration was...
ORGANISM(S): Homo sapiens (Human) 
2019-11-01 | PXD009644 | Pride
Cancer Drug Proteomics Mass spectrometry A549 Resource Expression Chemotherapeutic Database Compound 
ProteomicsProTargetMiner: A proteome library of anticancer molecules for functional discovery
As a further development of our Functional Identification of drug Targets by Expression Proteomics (FITExP) method, a reference dataset was built of the proteomic responses of A549 human adenocarcinoma cells to 56 clinical and experimental anticancer molecules. For each molecule, a concentration was...
ORGANISM(S): Homo sapiens (Human) 
2019-11-01 | PXD009775 | Pride
Cancer Drug Proteomics Mass spectrometry A549 Resource Expression Chemotherapeutic Database Compound 
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