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ProteomicsFOXA1 directs H3K4 monomethylation at enhancers via recruitment of the methyltransferase MLL3
FOXA1 is a pioneer factor that is important in hormone dependent cancer cells to stabilise nuclear receptors, such as estrogen receptor (ER) to chromatin. FOXA1 binds to enhancers regions that are enriched in H3K4mono- and dimethylation (H3K4me1, H3K4me2) histone marks and evidence suggests that the...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005253 | Pride
Foxa1 H3k4 Mll3 Human Lcmsms 
ProteomicsARID1A RIME in human cell lines and tissue xenografts.
Examination of chromatin-bound proteins associated with ARID1A, BRG1 and ERa in MCF7 cells and ERa in ER+ patient-derived xenografts using RIME protocol and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD011810 | Pride
Human Arid1a Rime Qplex 
ProteomicsIL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer
Interleukin 6 (IL6) signaling has been associated with an aggressive and metastatic phenotype in multiple solid tumors including breast cancer, but its mechanism of action in mediating tumor progression and treatment response is not clear. By exploiting a clinically relevant intraductal xenograft mo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012980 | Pride
Cancer Il6 Stat3 Metastasis 
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