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Aggresome is a para nuclear inclusion body that functions as a storage compartment for misfolded proteins. Our previous work revealed the presence of aggresomes in pediatric choroid plexus tumors (CPT). CPTs are rare neoplasms comprised of three pathological subgroups; choroid plexus carcinoma (CPC)...
ORGANISM(S): Homo sapiens (Human) 
2021-02-11 | PXD021076 | Pride
Gene expression data from normal mouse choroid plexus, choroid plexus papilloma and choroid plexus carcinoma
These tissue were harvested to complement and extend the studies that generated GSE23093. They served 3 purposes; 1) identify genes important to choroid plexus function and compare them with those important for meninges and associated vasculature (MAV) function, 2) determine genes in the choroid pl...
ORGANISM(S): Rattus norvegicus 
ZIC4 is a transcription factor related to pathways like NOTCH and Sonic Hedgehog (Shh) pathways which are involved in choroid plexus carcinoma (CPC). The current study describes the effect of ZIC4 gene re-expression on a CPC cell line proteome. We performed SILAC-based proteomics of ZIC4-transfected...
ORGANISM(S): Homo sapiens (Human) 
2024-07-26 | PXD043748 | Pride
Methylation profiling of choroid plexus carcinoma cell lines
Choroid plexus carcinomas (CPC) are poorly understood and frequently lethal brain tumors with minimal treatment options. Using a new mouse model of the disease and a large cohort of human CPCs [GSE60892; GSE60899], we performed a cross-species, genome-wide search for novel oncogenes within syntenic...
ORGANISM(S): Mus musculus 
Atoh1-Cre; Myc/Myc mice developed choroid plexus papilloma and Atoh1-Cre; Myc/Myc; p53fl/fl mice developed choroid plexus carcinoma. By studying the gene expression profiles of normal choroid plexus, choroid plexus papilloma and choroid plexus carcinoma in mice, we aim to gain a better understanding...
ORGANISM(S): Mus musculus 
2019-05-01 | GSE126327 | GEO
Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma
Methylation profiling of pediatric choroid plexus tumors
Aggresome is a para nuclear inclusion body that functions as a storage compartment for misfolded proteins. Our previous work revealed the presence of aggresomes in pediatric choroid plexus tumors (CPT). CPTs are rare neoplasms comprised of three pathological subgroups; choroid plexus carcinoma (CPC)...
ORGANISM(S): Homo sapiens 
2021-01-21 | GSE156090 | GEO
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