Sort   by:  
 Page size 
ProteomicsmTORC2-driven chromatin cGAS mediates chemoresistance in colorectal cancer
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited. However, the mechanisms underlying cGAS recruitment to chromatin and the functions of chromatin-bound cGAS (ccGAS) re...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053068 | Pride
Mtorc2 Chromatin cgas Phosphorylation Kga Chemoresistance 
ProteomicscGAS Senses Translation Stress Through Direct Binding to Ribosomes
The cGAS-STING pathway, a central component of the innate immune system, senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to mediate inflammation. Here we report the unexpected discovery that cGAS senses dysfunctional protein production. Purified ribosomes interact with and stimul...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019359 | Pride
Ribosomes Ascc Human Cgas 
UnknownPhosphorylation and chromatin tethering prevent cGAS activation during mitosis.
Not available
S-EPMC8171060 | biostudies-literature
UnknownRSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth.
Not available
S-EPMC11492232 | biostudies-literature
UnknownAntecedent chromatin organization determines cGAS recruitment to ruptured micronuclei.
Not available
S-EPMC9894866 | biostudies-literature
UnknownChromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells.
Not available
S-EPMC8640936 | biostudies-literature
UnknownmTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer.
Not available
S-EPMC11392818 | biostudies-literature
ProteomicsIdentification of cGAS post-translational modifications
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD017133 | panorama
UnknownInnate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Not available
S-EPMC5826565 | biostudies-literature
UnknownSensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection.
Not available
S-EPMC8564796 | biostudies-literature
Sort   by:  
 Page size