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GenomicsA role for H3K4 mono-methylation in facultative heterochromatin assembly and partitioning of chromatin readers
Mono-methylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Remarkably, we find H3K4me1 at the promoter regions of conditionaly-repressed muscle and stimulus-dependent inflammatory response genes in myoblasts. Durin...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-50590 | biostudies-arrayexpress
ProteomicsIdentification of mono-ADPr readers by multilevel chromatin proteomics
We performed multilevel proteomics to identify mono-ADPr readers. Pulldowns using ADPribosylated peptides and nucleosomes, analysis of the chromatin proteome using targeted modulations of the ADPr system (H2O2 treatment, ARH3 KO, HPF1 KO). We reveal multiple mono-ADPr readers, including RNF114, a ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD037026 | Pride
Adpribosylation Histone marks Human Ptm Mono-adpr Chromatin Lc-ms/ms 
UnknownThe Speckled Protein (SP) Family: Immunity's Chromatin Readers.
Not available
S-EPMC8327362 | biostudies-literature
ProteomicsDynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC) and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass spectrometry-based proteomics to identify readers for mC and hmC in mouse embry...
ORGANISM(S): Mus musculus (Mouse) 
2013-02-26 | PXD000143 | Pride
5-hydroxymethylcytosine Differentiation Stem cells Chromatin readers Quantitative mass spectrometry 
UnknownDecoding chromatin states by proteomic profiling of nucleosome readers.
Not available
S-EPMC10954555 | biostudies-literature
UnknownReading Cancer: Chromatin Readers as Druggable Targets for Cancer Treatment.
Not available
S-EPMC6356452 | biostudies-literature
UnknownTargeting chromatin readers.
Not available
S-EPMC4310568 | biostudies-literature
GenomicsAF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress
ProteomicsA phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution
Histones and associated chromatin proteins have essential functions in eukaryotic genome organization and regulation. Despite this fundamental role in eukaryotic cell biology, we lack a phylogenetically-comprehensive understanding of chromatin evolution. Here, we combine comparative proteomics and g...
ORGANISM(S): Acanthamoeba castellanii Sycon ciliatum Phytophthora infestans Thecamonas trahens Dictyostelium discoideum (Slime mold) Chlamydomonas reinhardtii Physcomitrella Nitrososphaera viennensis Bigelowiella natans Homo sapiens (Human) Methanobrevibacter cuticularis Gefionella okellyi Corallochytrium limacisporum Guillardia theta Naegleria gruberi Capsaspora owczarzaki Emiliania huxleyi Spizellomyces punctatus Methanospirillum stamsii Thalassiosira pseudonana Fabomonas tropica 
2022-08-12 | PXD031991 | Pride
Proteogenomics Histones Evolution Chromatin 
UnknownGenomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers.
Not available
S-EPMC11260483 | biostudies-literature
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