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ProteomicsIdentification of mono-ADPr readers by multilevel chromatin proteomics
We performed multilevel proteomics to identify mono-ADPr readers. Pulldowns using ADPribosylated peptides and nucleosomes, analysis of the chromatin proteome using targeted modulations of the ADPr system (H2O2 treatment, ARH3 KO, HPF1 KO). We reveal multiple mono-ADPr readers, including RNF114, a ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD037026 | Pride
Adpribosylation Histone marks Human Ptm Mono-adpr Chromatin Lc-ms/ms 
ProteomicsAn HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation
Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive PTM in essential cellular processes. Here we describe a phospho-guided chemoenzymatic approach based on the Ser-ADPr writer complex for rapid, scalab...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD020589 | Pride
Parp1 Lc-ms Fusion Adp-ribosylation 
ProteomicsSerine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signaling
In the mammalian DNA damage response, ADP-ribosylation signaling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors. Specifically, the PARP1:HPF1 complex recognizes damaged DNA and catalyzes the formation of serine-linked ADP-ribosylation marks (mono...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-05-26 | PXD036512 | Pride
Proteomics Adpr Ethcd Parp Drosophila Parg Af1521 Adp-ribosylation 
Transcriptomics PARG regulates the proteasomal degradation of TARG1
ADP-ribosylation is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteostasis. While the roles of ADPr transferases such as PARP1/2 and TNKS1/2 are well established, the functions and regulatory mechanisms of ADPr hydrolases are s...
ORGANISM(S): Homo sapiens 
2025-11-25 | GSE310746 | GEO
ProteomicsSerine ADP-ribosylation on histones and PARP1 is a cellular target for ester-linked ubiquitylation
ADP-ribosylation and ubiquitylation are key regulators of a wide variety of cellular processes, with the sophistication of their interplay becoming increasingly prominent, as illustrated by ADP-ribosylation-dependent ubiquitylation mediated by Legionella effectors. Recent biochemical studies have re...
ORGANISM(S): Homo sapiens (Human) 
2025-06-11 | PXD058858 | Pride
Adpr Dia Dda 
UnknownSerine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling.
Not available
S-EPMC10238386 | biostudies-literature
UnknownSerine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
Not available
S-EPMC8683085 | biostudies-literature
UnknownRNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation.
Not available
S-EPMC12583694 | biostudies-literature
ProteomicsPARG regulates the proteosomal degradation of TARG1
ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteostasis. While the roles of ADPr transferases such as PARP1/2 and TNKS1/2 are well established, the cellular functions and regulatory mechanisms of ADPr ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-02 | PXD065407 | Pride
Parp Ubiquitination Proteome Adp-ribosylation Proteasomal degradation Dna damage 
UnknownBehavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
Not available
S-EPMC7916507 | biostudies-literature
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