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TranscriptomicsUBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency,...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-59376 | biostudies-arrayexpress
GenomicsA long noncoding RNA regulates sister chromatid cohesion [ChIP-seq]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81600 | biostudies-arrayexpress
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
ProteomicsCST interacts with the cohesin complex and promotes chromosome cohesion
Sister chromatid cohesion (SCC), the pairing of sister chromatids following DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregation defects and aneuploidy. However, how SCC is...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD026264 | Pride
Fork stalling Chromosome cohesion Cst Ctc1 Stn1 Cohesin Ten1 Dna replication 
GenomicsThe Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [Mnase-seq]
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex MNase digestion of purified DNA followed by paired-end sequencing was performed in order to investigate geno...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-56992 | biostudies-arrayexpress
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
TranscriptomicsBudding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [PK-ChIP]
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-22 | E-GEOD-42457 | biostudies-arrayexpress
GenomicsThe Scc2NIPBL/Scc4MAU2 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions [ChIP-seq]
The Scc2/Scc4 complex binds to broad nucleosome-free regions in the promoters of highly expressed genes. The cohesin loader is recruited to these sites by the RSC chromatin remodeling complex ChIp- Sequencing analysis of the distribution of Scc2 and Scc4 on budding yeast chromosomes.An input sample ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-56993 | biostudies-arrayexpress
TranscriptomicsBudding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [expression]
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-22 | E-GEOD-42458 | biostudies-arrayexpress
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
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