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TranscriptomicsCharacterization of AGO1-/AGO4-associated smRNAs
To fully characterize smRNAs associated with AGO1 and AGO4, we developed a two-step protocol to purify AGO/smRNA complexes from flowers, leaves, roots and seedlings with enhanced purity, and sequenced the smRNAs by IlluminaM-CM-"M-BM-^@M-BM-^Ys technology. We identified some additional miRNAs, colla...
ORGANISM(S): Arabidopsis thaliana 
2011-04-19 | E-GEOD-28591 | biostudies-arrayexpress
UnknownExtended renal outcomes with use of iodixanol versus iohexol after coronary angiography.
Not available
S-EPMC4142278 | biostudies-literature
TranscriptomicsInsulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-M-NM-:B Pathway in Pancreatic Ductal Adenocarcinoma
IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role of IGFBP2 and its related pathways in PDAC. Gene expression profiling were used to reveal the key signaling pathways. Microarray experiments in IGFBP2-overexpressing ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-64611 | biostudies-arrayexpress
ProteomicsTandem Mass Tag approach utilizing pervanadate BOOST channels delivers deeper quantitative characterization of the tyrosine phosphoproteome
Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led to poor pTyr peptide identification and quantitati...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD016192 | Pride
Superbinder Trigger channel Phosphotyrosine proteomics Tandem mass tags Pervanadate 
ProteomicsColorectal Cancer Organoid Proteomics
Cyclin Dependent Kinases CDK8 and CDK19 (Mediator kinase) are regulatory components of the Mediator complex, a highly conserved complex that fine tunes transcriptional output. While Mediator kinase has been implicated in the transcriptional control of key pathways necessary for development and growt...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD030256 | Pride
Mouse Colorectal cancer Proteomics 
ProteomicsArabidopsis thaliana proteomics/phosphoproteomics
Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited. Here, we generated transgenic Arabidopsis thaliana pla...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-10-20 | PXD001252 | Pride
Arabidopsis thaliana Phosphorylation Mapk Leaf Lc-ms/ms 
ProteomicsFunctional states in tumor-initiating cell differentiation in human colorectal cancer
Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell mRNA-sequencing (scRNA-seq) of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. C...
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD018230 | Pride
Tumor heterogeneity Transcriptional programs Colorectal cancer Tumor cell differentiation Patient-derived cancer models Tumor-initiating cells Tumor metabolism Single-cell rna-sequencing 
ProteomicsNanoTACs: NanoLuc-Targeting Protein Degraders that Parallel Existing Technology
NanoLuc-targeting PROTACs (NanoTACs) hijack the CRBN and VHL cullin-RING ligase complexes to trigger proteasomal degradation of substrates tagged with the 19 kDa luminescent NanoLuc tag. In order to validate the system and confirm selective degradation of the target protein and assess any potential ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031371 | Pride
Lc-ms Human Protac 
UnknownRobust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score.
Not available
S-EPMC9903430 | biostudies-literature
ProteomicsQuantitative interactomics of Lck-TurboID in living human T cells unveils T cell receptor stimulation-induced proximal Lck interactors
While Lck has been widely recognized to play a pivotal role in the initiation of the T cell receptor (TCR) signaling pathway, an understanding of the precise regulation of Lck in T cells upon TCR activation remains elusive. Investigation of protein-protein interaction (PPI) using proximity labeling ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-12 | PXD020759 | Pride
Proximity labeling T cell receptor Lck Turboid Interactome 
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