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ProteomicsStructural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
G protein-coupled receptors (GPCRs) are the largest receptor superfamily that can propagate various extracellular stimulus into cells by coupling with heterotrimeric G proteins. G proteins are divided into four families, Gs, Gi/o, Gq/11 and G12/13, which are responsible for the transduction of discr...
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD019367 | Pride
Primary couplling Secondary coupling Gpcr G protein Hdx-ms 
ProteomicsMolecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2
G protein-coupled receptors (GPCRs) are essential signaling molecules involved in various physiological processes, with β-arrestins playing crucial roles in receptor desensitization, internalization, and G protein-independent signaling. Although the interaction between the phosphorylated C-terminal ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD056442 | Pride
Arrestin Dopamine receptor d2 Phosphorylated intracellular loop 3 Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 
ProteomicsMolecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
Arrestins are a protein family that regulate G protein-coupled receptor (GPCR) signaling, with four distinct members in mammals (arrestin 1–4). Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in C-terminus release. This induces further allosteric co...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-15 | PXD049391 | Pride
Arrestin Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 5-bisphosphate Phosphatidylinositol 4 
ProteomicsMolecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets given their involvement in numerous physiological processes and diseases. Although a cryo-electron microscopy study previously defined the structure of the M3-miniGq complex, the lack of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD042562 | Pride
Hdx-ms M3 G protein Gq Gpcr 
ProteomicsThe interactions between β-Arrestin 1 and Gαs or Gαi1: functional and structural insights
G proteins and arrestins are key G protein-coupled receptor (GPCR) signaling transducers, mediating distinct downstream pathways. Recent evidence suggests that G proteins and β-arrestins (βarrs) can directly or functionally interact through GPCR–G protein–βarr megaplexes, direct βarr1–Gαs interactio...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD065019 | Pride
G protein Protein–protein interaction Aarrestin Gpcr signaling 
UnknownWhole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape.
Not available
S-EPMC8263564 | biostudies-literature
UnknownRare variant contribution to the heritability of coronary artery disease.
Not available
S-EPMC11464707 | biostudies-literature
UnknownTransethnic genome-wide scan identifies novel Alzheimer's disease loci.
Not available
S-EPMC5496797 | biostudies-literature
UnknownMulti-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Not available
S-EPMC12273372 | biostudies-literature
UnknownAssessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
Not available
S-EPMC9119698 | biostudies-literature
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