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Data from ProteomeXchange, PXD ID: PXD001972. Experiment: male, file: MALE_PROSTATE_MID.msf.mgf. Published as part of PLoS One. 2015 May 14;10(5):e0126243 . From the Abstract: {{i}} Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases becau...
ORGANISM(S): Homo_sapiens_viruses, Rhesus_monkey_papillomavirus_1_uid14025, Rhesus 
The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...
ORGANISM(S): Mus musculus 
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress and progressively develop traits similar to those observed following an acute and strong oxidativ...
ORGANISM(S): Mus musculus 
60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary ...
ORGANISM(S): Homo sapiens 
To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full l...
ORGANISM(S): Mus musculus 
NAA15 is a component of the NatA complex that acetylates amino terminal (Nt) protein residues and influences protein synthesis. We identified multiple damaging NAA15 variants in congenital heart disease patients, including four loss-of-function (LoF) variants, one missense (R276W) de novo variant an...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD017672 | Pride
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the conse...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024957 | Pride
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