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TranscriptomicsRNA-seq of Glioma Neural Stem (GNS) cell line G144 after MEK inhibition in wild type (WT) and CIC (Capicua) depleted cells.
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6681 | biostudies-arrayexpress
GenomicsChIP-seq of CIC (Capicua) and histone marks (H3K9ac, H3K27ac and H3K4me1) in glioma neural stem cells (GNS) G144, human foetal neural stem cells (hNSC) and mouse embryonic stem cells (mESC),
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6682 | biostudies-arrayexpress
ProteomicsERK inhibits Cic repressor function via multisite phosphorylation
The receptor tyrosine kinase (RTK)/Extracellular Signal-Regulated Kinase (ERK) signaling pathway controls cell proliferation, differentiation, and survival. How ERK activation is relayed to its phosphorylation targets is not well understood. The transcriptional repressor Capicua (Cic) has emerged as...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-03-16 | PXD066179 | Pride
Erk Multisite phosphorylation Capicua Drosophila 
ProteomicsMulti-omic analyses reveal interaction networks linking CIC to cell cycle regulation
CIC encodes a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, indicating that it may function as a tumor suppressor. Recent data indicate that CIC may regulate cell cycle genes in humans; however, a thorough investigation of this proposed role has not yet...
ORGANISM(S): Homo sapiens (Human) 
2023-06-30 | PXD030942 | Pride
Protein-protein interaction Genetic interaction network Cell cycle Cic Single-cell sequencing 
TranscriptomicsRole of Capicua in metabolic system
CIC is a HMG box-containing transcriptional repressor evolutionarily conserved from C. elegans to human. It's known to associate with various types of cancer but physiological function of CIC remain largely unknown. In this study, we characterized Cic hypomorphic (Cic-L-/-) mice and identified criti...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-60375 | biostudies-arrayexpress
GenomicsCIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas [RNA-seq]
CIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas [RNA-seq]
PRJNA1041795 | ENA
GenomicsCIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas [ChIP-seq]
CIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas [ChIP-seq]
PRJNA1041445 | ENA
GenomicsGruber-CIC WGS - samples
WGS files for CIC paper titled "Malignant progression of an ancestral bone marrow clone harboring a CIC-NUTM2A fusion in isolated myeloid sarcoma"
EGAD00001009787 | EGA
GenomicsGruber-CIC RNASEQ - samples
RNASeq files for CIC paper titled "Malignant progression of an ancestral bone marrow clone harboring a CIC-NUTM2A fusion in isolated myeloid sarcoma"
EGAD00001009788 | EGA
GenomicsGeobacillus thermocatenulatus strain:CIC-2
Geobacillus thermocatenulatus strain:CIC-2 Genome sequencing
PRJNA263017 | ENA
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