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ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063036 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063031 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063029 | Pride
Lysosome Fgf Chordrocytes 
ProteomicsTranscriptional regulation of FAM134B by TFEB/TFE3 controls ER-phagy in response to starvation and chondrocyte differentiation
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function1. The recent identification of ER-phagy receptors has shed light on the molecular mechanism underlining this process; however, the signaling pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015326 | Pride
Lysosome Tfeb Er-phagy Chondrocyte 
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