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Many studies have demonstrated the importance of circRNA in regulating gene expression through functioning as microRNA sponges. However, the roles of circRNA-protein interaction are not fully understood. Importantly, how circRNA-protein interaction contributes the progression of pancreatic ductal ad...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD015048 | Pride
Role of mRNA-interacting circRNA in C2C12 muscle cell differentiation
Circular RNAs (circRNAs), a noncoding RNA class originating from alternative splicing, are highly abundant in neural tissues and were shown to regulate gene expression e.g. by interacting with microRNAs and RNA-binding proteins. Neuroblastoma is an embryonal neoplasia, which arises from undifferenti...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD026053 | Pride
CircRNA pulldown assays were conducted to identify proteins interacting with circMAN1A2_009. In summary, HeLa cell protein extracts were incubated with biotin-labeled circMAN1A2_009 probes obtained from Tsingke Biotechnology, China, at room temperature for 1h. Subsequently, streptavidin magnetic bea...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052372 | Pride
Identification of interacting proteins of circRNA-encoded proteins
ORGANISM(S): Mus Musculus 
This project submits the proteomic dataset of proteins interacting with the specific circular RNA Circ-018468, identified by ChIRP-MS (Chromatin Isolation by RNA Purification coupled with Mass Spectrometry). The experiment was performed using cell samples, with a negative control (non-specific probe...
ORGANISM(S): Mus Musculus 
2025-12-23 | PXD072338 |
Circular RNAs (circRNAs), a noncoding RNA class originating from alternative splicing, are highly abundant in neural tissues and were shown to regulate gene expression e.g. by interacting with microRNAs and RNA-binding proteins. Neuroblastoma is an embryonal neoplasia, which arises from undifferenti...
RNA-protein interactions play essential roles in regulating a wide range of cellular processes. Profiling the protein interactome of specific RNA loci enables understanding the underlying molecular mechanisms of RNA regulatory processes. Here we describe an RNA-centric proximity labeling approach fo...
ORGANISM(S): Homo sapiens 
2025-06-04 | GSE237019 | GEO
In the intricate landscape of Alzheimer’s disease (AD) pathology, circular RNAs(circRNA) are emerging as influential players, orchestrating crucial aspects of gene expression, synaptic plasticity, and neuronal function. In this study, we characterize the biological role of circPDE4B, a highly abunda...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD070615 | Pride
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