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ProteomicsSecretome analysis of C-mannosyltransferase-deficient hiPSCs
C-mannosylation is a modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. To date, only few proteins have been proven to be C-mannosylated and studies aiming at global assessment of protein C-mannosylation from cells or tissues are scarce. I...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024193 | Pride
Hipscs Dpy19l3 Secretomics Dpy19l1 Tsr C-mannosylation 
ProteomicsWhole cell proteome analysis of Huh-7 Lunet and HEK293 cells
O’nyong-nyong virus (ONNV) is an arthritogenic alphavirus whose replication depends on host cell factors. In this study, we investigated the cellular basis underlying the restricted replication of ONNV in human hepatoma Lunet cells compared to permissive HEK293 cells. To identify host factors assoc...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD074273 | Pride
Huh-7 lunet Hek293 Onnv host factors 
ProteomicsIntegrative multi-omics analysis of growth plate regulation underlying body size in miniature pigs
Body size represents a complex phenotype driven by genetic variation and epigenetic regulation, with the molecular processes underlying this trait remaining a central challenge to disentangle. To elucidate these fundamental mechanisms, we applied a multi-omics approach to investigate the regulatory ...
ORGANISM(S): Sus scrofa (Pig) 
2026-06-11 | PXD069390 | Pride
Miniaturization Growth Miniature pigs Functional genomics Multi-omics Gene regulation Body size Growth plates 
ProteomicsThrombospondin repeats secreted by C-mannosyltransferase-deficient mammalian cells
C-mannosylation in addition to N- and O-glycosylation is a further but less well studied type of protein glycosylation taking place in the endoplasmic reticulum (ER) characterised by the modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. M...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024192 | Pride
Thbs1 Dpy19l3 Adamts16 C-mannosylation Dpy19l1 Tsr 
ProteomicsEndogenous THBS1 is C-mannosylated by human induced pluripotent stem cells.
We used a human thrombospondin-1 (THBS1) fragment comprising thrombospondin type 1 repeats (TSRs) 1 to 3, which was recombinantly expressed in HEK 293T cells and digested with AspN to determine chromatographic retention times and to optimise MS parameters. We detected two peptides from TSR2 and TSR3...
ORGANISM(S): Homo Sapiens 
2021-05-12 | PXD024117 | panorama
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