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MetabolomicsCOSY catalyzes trans-cis isomerization and lactonization in the biosynthesis of coumarins

Coumarins or 1,2-benzopyrones comprise a large class of secondary metabolites ubiquitously found in the plant kingdom. In many plant species, coumarins are particularly important for iron acquisition and plant defense. Here we show that COUMARIN SYNTHASE (COSY) is a key enzyme in the biosynthesis...

2019-08-08 | MTBLS692 | MetaboLights
TranscriptomicsTranscription profiling of human sebocytes (SEB-1) treated with 13-cis retinoic acid treatment
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Su...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10432 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin from patients with acne before and 1 week after isotretinoin (13-cis retinoic acid) treatment
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Su...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-10433 | biostudies-arrayexpress
ProteomicsCIS deficiency intensifies GM-CSF signaling to polarize alternative activated macrophages
GM-CSF paradoxically possesses ability to differentiate both classically activated macrophages (MØs) with dominant proinflammatory function (M1-like MØs) and alternative activated MØs with strong immunosuppressive function (M2-like MØs). The intrinsic regulatory mechanism responsible for functional ...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-21 | PXD018390 | Pride
Cis Gm-csf Macrophage polarization Tumour immunity 
TranscriptomicsTranscription profiling of human immortalized sebocytes (SEB-1) treated with 13-cis retinoic acid to gain insights into its sebocyte-specific mechanism of action
This SuperSeries is composed of the following subset Series:; GSE10432: 13-cis retinoic acid treatment of human sebocytes (SEB-1); GSE10433: Human Skin: Before and 1 week after Isotretinoin Treatment; The pathogenesis of acne has been linked to multiple factors such as increased sebum production, in...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10434 | biostudies-arrayexpress
Transcriptomicscis sequence effects on gene expression
Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence varia...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-8394 | biostudies-arrayexpress
ProteomicsPrediction and experimental validation of a new salinity-responsive cis-regulatory element (CRE) in tilapia
Quantitative DIA proteomics in combination with the transcription inhibitor actinomycin D was performed on the tilapia OmB cell line to identify proteins that are upregulated by transcriptional regulation during hyperosmotic stress. This analysis revealed proteins that are transcriptionally up-regul...
ORGANISM(S): Oreochromis Mossambicus 
PXD032181 | panorama
TranscriptomicsTranscription profiling of E. coli planktonic samples exposed to cis-1,2-dichloroethylene (cis-DCE)
Metabolically-engineered Escherichia coli has been used previously to degrade the ubiquitous pollutant cis-1,2-dichloroethylene (cis-DCE), and the impact of the metabolic engineering was assessed by investigating the changes in the proteome. Here, genome-wide transcriptome analysis was performed to...
ORGANISM(S): Escherichia coli 
2009-11-27 | E-GEOD-13698 | biostudies-arrayexpress
TranscriptomicsThe role of cis regulatory evolution in Zea Mays domestication
Modification of cis regulatory elements to produce differences in gene expression level, localization, and timing is an important mechanism by which organisms evolve divergent adaptations. To examine gene regulatory change during the domestication of maize from its wild progenitor, teosinte, we asse...
ORGANISM(S): Zea mays 
2014-11-06 | E-GEOD-61810 | biostudies-arrayexpress
TranscriptomicsNatural selection on cis and trans regulation in yeasts
Gene expression is regulated both by cis elements, which are DNA segments closely linked to the genes they regulate, and by trans activating factors, which are usually proteins capable of diffusing to unlinked genes. Understanding the patterns and sources of regulatory variation is crucial for under...
ORGANISM(S): Saccharomyces cerevisiae 
2010-04-02 | E-GEOD-20749 | biostudies-arrayexpress
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