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ProteomicsCitrullinated proteins in platelets and platelets releasing microparticles may serve as a potential target of ACPA
To investigate the expression of peptidylarginine deiminase (PAD) enzymes and mining citrullination proteins in human platelets and platelets releasing microparticles (PRMs), and to determine whether these less-studied platelets associated citrullination proteins can be targeted by anti-citrullinate...
ORGANISM(S): Homo Sapiens 
2022-10-26 | PXD037743 |
ProteomicsMice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies
Synovial antigen arrays were probed with 1:150 dilutions of plasma derived from SJL mice immunized with fibrinogen emulsified in CFA or with CFA alone. Autoantibody binding was detected with a Cy3-conjugated goat-anti-mouse IgG/M secondary antibody. SAM was applied to identify antigens with statis...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18023 | biostudies-arrayexpress
ProteomicsConfident identification of citrullinated peptides from P gingivalis
Porphyromonas gingivalis is a key pathogen in the development of chronic periodontitis and has recently been linked to the development of rheumatoid arthritis and Alzheimer’s disease. In this project the outer membrane vesicles (OMV) from Pg have been analyzed using a two-dimensional HFBA-based sepa...
ORGANISM(S): Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 
2019-11-22 | PXD015701 | Pride
Citrullination Citrulline Hfba Phorphyromonas gingivalis Proteins 
UnknownChemical Proteomic Platform To Identify Citrullinated Proteins.
Not available
S-EPMC4729336 | biostudies-literature
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - macrophage samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-09 | PXD035177 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - human synovium fluids samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD035180 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
GenomicsCitrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D
Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D
PRJNA1204949 | ENA
UnknownPhenylglyoxal-based visualization of citrullinated proteins on Western blots.
Not available
S-EPMC6272700 | biostudies-literature
ProteomicsAutoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis [ANALYTE: ANTIGEN]
Rheumatoid arthritis is a prototypical autoimmune arthritis affecting nearly 1% of the world population and is a significant cause of worldwide disability. Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of immunol...
ORGANISM(S): Homo sapiens 
2011-09-09 | E-GEOD-32016 | biostudies-arrayexpress
TranscriptomicsCitrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D
Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. However, there remains limited understanding regarding specific citrullinated proteins a...
ORGANISM(S): Homo sapiens 
2025-01-03 | GSE285602 | GEO
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