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ProteomicsA piRNA like small RNA interacts with and modulates p-ERM proteins in human somatic cells
PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC...
ORGANISM(S): Homo sapiens (Human) 
2015-09-03 | PXD002076 | Pride
Human Pull-down Lc-ms/ms 
ProteomicsEvaluation of NCI-7 Cell Line Panel
Reference materials are vital to benchmarking the reproducibility of clinical tests and essential for monitoring laboratory performance for clinical proteomics. The reference material utilized for mass spectrometric analysis of the human proteome would ideally contain enough proteins to be suitably ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD008952 | Pride
Nci-60 Proteomics reference standard Nci-7 Cptac 
ProteomicsBreast cancer exosome protein profiling using TMT quantitation and SVM analysis
Exosomes are microvesicles of endocytic origin constitutively released by multiple cell types into the extracellular environment. With evidence that exosomes can be detected in the blood of patients with various onco-malignancies, the development of a platform that uses exosomes as a diagnostic tool...
ORGANISM(S): Homo sapiens (Human) 
2015-10-02 | PXD002053 | Pride
Human Exosomes Tmt quantitation Breact cancer 
TranscriptomicsTranscription profiling of melanized domamine neurons isolated from male and female patients with Parkinson disease to investigate gender differences
We used 500 melanized dopamine neurons isolated from post-mortem human substantia nigra pars compacta of each sample with laser capture microdissection. Total RNA was extracted with Arcturus PicoPure RNA extraction kit and amplified two times with Arcturus RiboAmp RNA amplification kit. the samples ...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-MEXP-1416 | biostudies-arrayexpress
ProteomicsTriple SILAC exosomal quantitative proteomic analysis
Exosomes are 30-100 nm sized membrane vesicles released by cells into extracellular space and mediate the intercellular communication via transfer of proteins and RNAs. To better understand the function of these microvesicles in lung carcinogenesis, we employed a Triple SILAC quantitative proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-12 | PXD003001 | Pride
Non-small cell lung cancer Silac Exosomes Quantitative proteomics 
TranscriptomicsEpigenetic events in early breast cancer
Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress
GenomicsInterrelationships between replication infidelity and genome composition
An enduring issue in evolutionary and cancer biology is how replication infidelity influences genome composition and vice versa. Here we examine this issue by sequencing the genomes of diploid budding yeast strains that are either mismatch repair (MMR) proficient or deficient and encode wild type or...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-25 | E-GEOD-56939 | biostudies-arrayexpress
UnknownLGBQ-affirmative cognitive-behavioral therapy for young gay and bisexual men's mental and sexual health: A three-arm randomized controlled trial.
Not available
S-EPMC9446477 | biostudies-literature
UnknownMetabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences.
Not available
S-EPMC5034715 | biostudies-literature
UnknownPrecursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family.
Not available
S-EPMC7268733 | biostudies-literature
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