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ProteomicsConfirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer
The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD061476 | Pride
Inhibitor Cdk19 Phosphoproteome Cdk8 Colorectal cancer 
ProteomicsProteome profiling followng targeting eIF4E
Here we have compared the impact of loss the protein synthesis initiation factor eIF4e in non samll cell lung cancer cells. Expression of eIF4E was targeted by an eIF4E siRNA or by expressiojn of eIF4E-dTAG construct allowing degradation of eIF4e-dTAG with the heterobifunctional dTAGv-1 small molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057122 | Pride
Human Cancer Lung Dtag Protein synthesis Eif4e Sirna 
TranscriptomicsAn Invasive Gene Expression Signature in Pancreas Cancer
Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress
ProteomicsMetabolic changes in adaptation to biofilm growth by streptococcus pneumoniae
Comparative analyses of protein expression between log-phase planktonic and 1-day and 7-day biofilm cultures from Streptococcus pneumoniae representing nascent and late phase biofilm growth were performed using the proteomic approach iTRAQ
ORGANISM(S): Streptococcus pneumoniae SP14-BS69 
2014-09-10 | PXD001182 | Pride
Biofilm Streptococcus pneumoniae 
TranscriptomicsRNA-seq of chemically reset human naive pluripotent stem cells
A simple method is presented to reset human pluripotent cells to a naive state via transient histone deacetylase inhibition and maintenance in chemically-defined naive stem cell culture media. Cells can be reset without transgenes and expanded continuously either on feeders or alternative substrates...
ORGANISM(S): Homo sapiens 
2017-08-07 | E-MTAB-5674 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis response to action(s) of nitric oxide
Nitric oxide (NO.) is a well-established signal in mammalian cells regulating e.g. smooth muscle tone, neurotransmission and apoptosis. NO interacts with superoxide (O2-) to derive the highly reactive peroxynitrite (ONOO-) radical leading to the generation of lipid hydroxy-peroxides (ROO.) and cell ...
ORGANISM(S): Arabidopsis thaliana 
2022-11-21 | E-NASC-55 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis - establishing the action(s) of nitric oxide in plants.
Nitric oxide (NO.) is a well-established signal in mammalian cells regulating e.g. smooth muscle tone, neurotransmission and apoptosis. NO interacts with superoxide (O2-) to derive the highly reactive peroxynitrite (ONOO-) radical leading to the generation of lipid hydroxy-peroxides (ROO.) and cell ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6170 | biostudies-arrayexpress
UnknownPurification and biochemical characterization of SM14est, a PET-hydrolyzing enzyme from the marine sponge-derived Streptomyces sp. SM14.
Not available
S-EPMC10213408 | biostudies-literature
UnknownIncidence of visual improvement in uveitis cases with visual impairment caused by macular edema.
Not available
S-EPMC3946576 | biostudies-literature
TranscriptomicsGene Expression and Comparative Genomic Hybridization of Ductal Carcinoma In Situ of the Breast
Background The dramatic increase in incidence of ductal carcinoma in situ (DCIS) associated with mammographic screening for breast cancer has given emphasis to the challenges of managing this important clinical entity. Unlike invasive breast cancer, there is no established histopathologic grading sy...
ORGANISM(S): Homo sapiens 
2008-11-24 | E-GEOD-7882 | biostudies-arrayexpress
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