Sort   by:  
 Page size 
ProteomicsPan-claudin family interactome analysis reveals shared and specific interactions
Interactome study of the pan-claudin family by combining two complementary pull-down techniques followed by mass spectrometry to create an interaction landscape of the claudin family. Co-immunoprecipitation (CoIP) of recombinant claudins expressed in MDCK-C7 cells provided information about interact...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2023-10-24 | PXD031094 | Pride
Lc-ms/ms Prisma Claudin Pulldown Interactome Peptide pulldown 
TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
TranscriptomicsClaudin-7 is frequently overexpressed in ovarian cancer and promotes invasion
Claudins are tight junction proteins that are involved in tight junction formation and function. Previous studies have shown that claudin-7 is frequently upregulated in epithelial ovarian cancer (EOC) along with claudin-3 and claudin-4. Here, we investigate in detail the expression patterns of claud...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-26055 | biostudies-arrayexpress
ProteomicsPhosphorylation of claudin-11 - Mass spectrometry analysis confirmed the phosphorylation of human claudin-11 at tyrosine 191 and tyrosine 192
Mass spectrometry analysis confirmed the phosphorylation of human claudin-11 at tyrosine 191 and tyrosine 192
ORGANISM(S): Homo sapiens (Human) 
2018-08-29 | PXD010908 | Pride
Claudin-11 Phosphorylation Human 
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
TranscriptomicsRNAseq on lungs from WT vs claudin 4 KO mice that underwent ventilator-induced lung injury
WT mice and claudin 4 KO mice were exposed to ventilator-induced lung injury (VILI) for 2 hours. We found that in some Cldn4 KO mice, injury was similar to WT, while in others, injury was higher, as assessed by amount of protein leak into broncho-alveolar lavage fluid. We performed RNAseq to find wh...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-50927 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of murine thymic type 1 dendritic cells from competitive bone marrow chimeras containing both claudin-1–deficient and claudin-1–sufficient cells
The goal of the experiment is to determine the impact of Claudin 1 deficiency on the gene expression of thymic type 1 dendritic cells.
ORGANISM(S): Mus musculus 
2025-08-08 | E-MTAB-15468 | biostudies-arrayexpress
TranscriptomicsThe Tight Junction Protein Claudin-2 Controls Mucosal Permeability, Immune Tolerance and Colitis in Mice
The mucosal epithelium plays a key role in regulating immune homeostasis. Dysregulation of epithelial barrier function is associated with mucosal inflammation. Expression of claudin-2, a pore-forming tight junction protein, is highly upregulated during inflammatory bowel disease (IBD) and, due to it...
ORGANISM(S): Mus musculus 
2013-09-15 | E-GEOD-46006 | biostudies-arrayexpress
Sort   by:  
 Page size