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GenomicT1DGC: Genome-Wide Association Study in Type 1 Diabetes, 2008

Cases with Type 1 Diabetes (T1D) in the UK, were part of the Wellcome Trust Case Control Consortium (WTCCC) - http://www.wtccc.org.uk - that first reported in 2007:

Wellcome Trust Case Control Consortium (2007) Genome-wide association s...

phs000180 | dbGaP
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - SILAC proteome profiling to determine the impact of acute AAK1/BMP2K inhibition
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055851 | Pride
Focal adhesions Lc-ms Silac Aak1 Migration Dda Bmp2k 
ProteomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Reduction in blood supply to the kidneys occurs to certain extent during kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. At present, no therapies exist to prevent the AKI to CKD transition. Here, we presen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD042882 | Pride
Acute kidney injury Metabolomics Organoids Chronic kidney disease Transcriptomics Maladaptive regeneration Proteomics Hypoxia 
UnknownComplex history of dog (Canis familiaris) origins and translocations in the Pacific revealed by ancient mitogenomes.
Not available
S-EPMC6002536 | biostudies-literature
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 interactome profiling
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055980 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration – PDLIM5 differential interactomics
PDLIM5 is a poorly explored protein, that has been shown to play a role in the maintenance of focal adhesions, likely through its interaction with actin. Our experiments demonstrate that AAK1 phosphorylates PDLIM5 on threonine 290 (T290). The aim of this experiment is to investigate the role of this...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055912 | Pride
Lc-ms Dia Co-immunoprecipitation Pdlim5 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 differential interactome profiling
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055873 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - LFQ proteome profiling to determine the impact of AAK1/BMP2K perturbation
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055831 | Pride
Focal adhesions Lc-ms Dia Aak1 Lfq Migration Bmp2k 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 C-terminal interactome profiling – batch 1
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD056027 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - AAK1 C-terminal interactome profiling – batch 2,3
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD056013 | Pride
Lc-ms Dia Co-immunoprecipitation Aak1 Interactomics 
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