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ProteomicsLineage-specific Protein Interactomes of the Hox Transcription Factor Ubx revealed by Close-Proximity Protein Biotinylation
Cell type diversity is controlled by transcription factors (TFs), which regulate specific yet flexible gene expression programs depending on the cellular environment. However, how sets of TFs work together to promote such diversity with high precision is still unknown. We used the Hox TF Ultrabithor...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-04-22 | PXD014481 | Pride
Close-proximity biotinylation Transcription Close-proximity partners Ubx Ppi Drosophila Interaction Interactome Bioid Ultrabithorax Proteomics Development Hox 
ProteomicsDefining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding
NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia (ALL) are...
ORGANISM(S): Homo sapiens (Human) 
2019-06-27 | PXD013759 | Pride
Interacting partners Label-free proteomics Nsd2 Bioid Multiple myeloma Lc-ms/ms 
UnknownLabel transfer reagents to probe p38 MAPK binding partners.
Not available
S-EPMC3762675 | biostudies-literature
UnknownProteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane.
Not available
S-EPMC6827323 | biostudies-literature
UnknownIdentification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.
Not available
S-EPMC8629785 | biostudies-literature
ProteomicsInteractome of CFTR using Apex and TurboID proximity labelling
The proteins interacting with CFTR and its mutants have been intensively studied using different experimental approaches, enabling to better understand the cellular processes leading to proper protein folding, routing to the plasma membrane, recycling, activation and degradation. Recently, several s...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035184 | Pride
Apex Turboid Kcnk3 Cftr Interactome 
ProteomicsProteomic proximity mapping by rapamycin-dependent targeting of APEX2
Enhanced ascorbate peroxidase 2 (APEX2) can be used as a genetic tag that produces short-lived yet highly reactive biotin species, allowing the modification of proteins that interact with or are in very close proximity to the tagged protein, ideally within a confined compartment. Biotinylated protei...
ORGANISM(S): Homo sapiens (Human) 
2020-04-15 | PXD009783 | Pride
Apex2 Mass spectrometry Proximity labeling Silac Apex 
ProteomicsProteomic proximity mapping by rapamycin-dependent targeting of APEX2 to tail-anchored membrane proteins
Enhanced ascorbate peroxidase 2 (APEX2) can be used as a genetic tag that produces short-lived yet highly reactive biotin species, allowing the modification of proteins that interact with or are in very close proximity to the tagged protein, ideally within a confined compartment. Biotinylated protei...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD012157 | Pride
Apex Vapb Mass spectrometry Proximity labeling 
GenomicsSOX4 and RELA function as transcriptional partners to regulate the expression of TNF-responsive genes in fibroblast-like synoviocytes [ChIP-Seq]
Purpose: Our goal was to evaluate the transcriptional profiles of FLS. We used genome wide approaches to uncover the interactions between SOX4 and RELA/p65, downstream of TNF signaling. Methods: ChIP-seq of mouse FLS was used to compare the global DNA binding profiles of SOX4 and RELA. Results: ChIP...
ORGANISM(S): Mus musculus 
2022-03-21 | GSE197491 | GEO
GenomicsSOX4 and RELA function as transcriptional partners to regulate the expression of TNF-responsive genes in fibroblast-like synoviocytes [ChIP-Seq]
SOX4 and RELA function as transcriptional partners to regulate the expression of TNF-responsive genes in fibroblast-like synoviocytes [ChIP-Seq]
PRJNA810559 | ENA
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