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ProteomicsProteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection
Antibody-mediated rejection (AMR) accounts for >50% of kidney allograft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the tubulointerstitium, which together with high interferon gamma (IFNɣ) and tumor necrosis factor-alpha (TNFα), trig...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD017580 | Pride
Glomeruli Basement membrane Glomerular microvascular endothelial cells Tubulointerstitium Systems biology Hla class-i Antibody-mediated rejection Biopsy Kidney Cathepsins. Laser-capture microdissection Proximal tubular epithelial cells Laminin Galectin-1 Glutathione s-transferase omega-1 Extracellular matrix Cytokines Remodeling Proteomics 
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo sapiens (Human) 
2017-01-17 | PXD003811 | Pride
Sex hormones Silac Kidney cells Proteomics 
ProteomicsCombined Protein Signature of ALDH1A1, LGALS3, LGALS3BP Predicts Cancer Recurrence Post-Liver Transplantation Beyond Milan Hepatocellular Carcinoma
Background: Liver transplantation (LT) for Hepatocellular carcinoma (HCC) can be offered to patients beyond Milan criteria. However, there are currently no molecular markers that can be used on HCC explant histology to predict recurrence, which arises in up to 20% of LT recipients. The goal of our s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD022881 | Pride
Hepatocellular carcinoma Proteomics Recurrence Liver Galectin 
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
ProteomicsUrinary PRM analysis of early type 1 diabetes
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis can be captured in the urinary peptidome. We thus examined the urinary peptidomes of otherwise healthy youths with type 1 ...
ORGANISM(S): Homo Sapiens 
2020-01-01 | PXD012389 | panorama
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