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ProteomicsDNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans
Assembly of the DNA helicase known as CMG (CDC45-MCM-GINS) is the key regulated step during DNA replication initiation in eukaryotes. Using the Caenorhabditis elegans embryo as a model system, we identify a new CMG assembly factor called DNSN-1, which associates with the BRCT-domain protein MUS-101...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD044240 | Pride
Donson C. elegans Meier gorlin syndrome Mus-101 Dnsn-1 Cmg helicase Dna replication 
ProteomicsConserved phosphorylation mechanism regulates the interaction between the Cdc45-MCM2-7-GINS (CMG) replicative helicase complex and its forked DNA substrate
Mapping of the Chk1 phosphorylation sites in Drosophila CMG in vitro with recombinant proteins
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-03-31 | PXD049048 | Pride
Cmg Chk1 Mcm2-7 
ProteomicsMcm7 ubiquitylation and Pif1-family helicases drive CMG disassembly to preserve genome integrity
Disassembly of the DNA helicase known as CMG (Cdc45-Mcm-GINS) is the key regulated step during DNA replication termination in eukaryotes. In budding yeast, CMG disassembly is initiated by the ubiquitin ligase SCF-Dia2, which ubiquitylates the Mcm7 subunit of CMG, leading to recruitment of the Cdc48...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-09 | PXD048935 | Pride
Ubiquitylation Dia2 Cmg helicase Cmg disassembly Pif1 S. cerevisiae Dna replication Rrm3 
UnknownThe mechanism of eukaryotic CMG helicase activation.
Not available
S-EPMC6847044 | biostudies-literature
UnknownIdentification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function.
Not available
S-EPMC10441460 | biostudies-literature
UnknownIdentification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function.
Not available
S-EPMC11532780 | biostudies-literature
UnknownReconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
Not available
S-EPMC8331092 | biostudies-literature
GenomicsMCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation
DNA replication initiation requires activation of the CMG helicase to establish the replisome. This process involves the extrusion of single-stranded DNA (ssDNA) from the central channel of MCM double hexamers, allowing the two CMG helicases to pass each other; however, the factors that mediate this...
ORGANISM(S): Homo sapiens 
2026-05-01 | GSE317126 | GEO
UnknownCMG helicase disassembly is essential and driven by two pathways in budding yeast.
Not available
S-EPMC11405719 | biostudies-literature
UnknownCMG helicase activity on G4-containing DNA templates.
Not available
S-EPMC9578012 | biostudies-literature
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