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TranscriptomicsDisplacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting
The ring-shaped cohesin complex links sister chromatids until their timely segregation during mitosis. Cohesin is enriched at centromeres, where it provides the cohesive counter-force to bi-polar tension produced by the mitotic spindle. As a consequence of spindle tension, centromeric sequences tran...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-29 | E-GEOD-8661 | biostudies-arrayexpress
ProteomicsCrosslinking/mass spectrometry (CLMS) analysis of Cohesin complex
The ring-shaped cohesin complex is thought to fulfil its roles in sister chromatid cohesion, genome stability and gene regulation by topologically encircling DNAs. The ring is formed by two Structural Maintenance of Chromosome (SMC) subunits, whose ATPase heads are linked by a kleisin subunit. Addit...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2020-08-04 | PXD018608 | Pride
Crosslinking/mass spectrometry Cohesin complex 
TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
ProteomicsStructure of the Cohesin Loader Scc2-Scc4 and its Binding to a Folded Cohesin
The functions of cohesin are central to genome integrity, chromosome organization, and transcription regulation through its prevention of premature sister-chromatid separation and the formation of DNA loops. The loading of cohesin onto chromatin depends on the Scc2-Scc4 complex, however, little is k...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-11 | PXD004692 | Pride
Cohesin Cross-linking Cx-ms 
GenomicsGenome-wide localization of Smc1, Smc3 and CTCF in mouse B cells.
Immunoglobulin class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation induced cytidine deaminase (AID) to switch regions and by the subsequent generation and resolution of dsDNA breaks (DSBs). During, CSR the IgH locus undergoes dynamic three-dimensional...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-43594 | biostudies-arrayexpress
TranscriptomicsBudding yeast cohesin (Mcd1) distribution in mitotically arrested cells
genomic localization of the budding yeast cohesin complex was mapped in mitotically arrested cells by Mcd1 ChIP followed by hybridization to high-density tiled microarrays Cells were synchronized first in G1 and then released into media containing the microtubule poison nocodazole. Cells were fixed ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-30 | E-GEOD-18021 | biostudies-arrayexpress
TranscriptomicsThe Cohesin Complex Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity
Embryonic stem cells (ESCs) cells run a self-renewal gene expression program, requiring the expression of certain transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptio...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-24030 | biostudies-arrayexpress
TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (sequencing)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42397 | biostudies-arrayexpress
TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (tiling)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42360 | biostudies-arrayexpress
GenomicsDose-dependent role of the cohesin complex in normal and malignant hematopoiesis [ATAC-Seq]
Cohesin complex members have recently been identified as putative tumor suppressors in hematologic and epithelial malignancies. The cohesin complex guides chromosome segregation, however cohesin-mutant leukemias do not show genomic instability. We hypothesized reduced cohesin function alters chromat...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-73215 | biostudies-arrayexpress
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