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TranscriptomicsDistinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle
MicroRNAs (miRNAs) are single-stranded non-coding RNAs that negatively regulate target gene expression through mRNA cleavage or translational repression. There is mounting evidence that they play critical roles in heart disease. The expression of known miRNAs in the heart has been studied at length ...
ORGANISM(S): Rattus norvegicus 
2014-03-28 | E-GEOD-56300 | biostudies-arrayexpress
ProteomicsProteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins
The sorting nexin SNX17 controls endosome-to-cell surface recycling of diverse transmembrane cargo proteins including integrins, the amyloid precursor protein and lipoprotein receptors. This requires association with the multi-subunit Commander trafficking complex, which depends on the C-terminus of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD036424 | Pride
Endosome Pdz domain Snx17 Commander Retriever Pdlim 
UnknownFully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification.
Not available
S-EPMC4491436 | biostudies-literature
ProteomicsMutations in the exocyst component EXOC2 (Sec5) cause severe defects in human brain development
The exocyst is an octameric protein complex and an essential component of the membrane transport machinery required for tethering vesicles at the plasma membrane prior to fusion. Here we report on pathogenic variants in one of the exocyst subunits, EXOC2 (Sec5), in unrelated families. Analysis of pa...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD017107 | Pride
Human Exoc2 Fibroblasts Tmt6plex 
TranscriptomicsTranscription profiling of Campylobacter jejuni flagellar mutants to investigate the RpoN and FliA regulons, and the flagellar hook length control gene fliK
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-50
ORGANISM(S): Campylobacter jejuni 
2007-09-06 | E-BUGS-50 | biostudies-arrayexpress
ProteomicsO-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD010820 | Pride
Hbp pathway Mass spectrometry Dna repair Shoga Lfq quantification Shogt O-glcnacylation Chromatin modification Q-exactive 
UnknownUpdated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Not available
S-EPMC6174113 | biostudies-literature
UnknownProtocol for serious fall injury adjudication in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study.
Not available
S-EPMC6582694 | biostudies-literature
UnknownRationale and Design of ORCHID: A Randomized Placebo-controlled Clinical Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.
Not available
S-EPMC7462324 | biostudies-literature
ProteomicsDual molecular mechanisms and functional compensation by RBMXL1 retrocopy underlie RBMX-associated neurodevelopmental syndrome
Genetic variants in RBMX may cause X-linked neurodevelopmental syndromes, but their pathogenicity and mechanisms remain unclear. Here, we provide definitive evidence from nine unrelated families that RBMX variants lead to neurodevelopmental disorders characterised by intellectual disability, brain m...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD066823 | Pride
Neurodevelopmental disorder Evolution Splicing Rbmx Rbmxl1 retrocopy 
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