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MetabolomicsPreoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

Kupffer cells from both Sed and PEx mice were harvested for Metabolomics. 3 weeks after tumor injection, both mice bearing MC38 tumors were sacrificed. The livers were harvested and processed into single-cell suspensions, and KCs were isolated.

2025-12-09 | MTBLS13419 | MetaboLights
TranscriptomicsWhole genome analysis for liver metastasis gene signitures in colorectal cancer
Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular events involved in tumor progression and metast...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-6988 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Primary Colorectal Cancers and associated Liver Metastases
Comparison of expression profiles of primary colorectal cancers with liver metastases of the same patient. Additionally, expression data of normal colon and liver tissue. Abstract of publication will be included upon publication Keywords: expression profiling, colorectal cancer, colon cancer, liver...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-14297 | biostudies-arrayexpress
ProteomicsPaladin, a pseudo-phosphatase overexpressed in colon cancer, is required for actin polymerization and liver metastasis dissemination
Colorectal cancer remains a public health issue and most of colon cancer patients succumb to the development of metastases. Using a specific protocol, we identified paladin as a potential colon cancer liver metastases biomarker. We then explored the biological function of paladin in colon cancer cel...
ORGANISM(S): Homo sapiens (Human) 
2022-07-27 | PXD030803 | Pride
Phosphoproteome Actin cytoskeleton Colon cancer Paladin 
ProteomicsDown-regulation of collagen hydroxylation in colorectal liver metastasis
Collagen, a major component of the extracellular matrix, is significantly upregulated in colorectal liver metastasis (CRLM) compared to liver tissue. Expression levels of specific collagen types in CRLM resemble those in colorectal cancer (CRC) and colon tissue. We investigated whether the collagen ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD015015 | Pride
Crlm Liver Human Ptm Crc Collagen Colon Orbitrap fusion 
OtherExtracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Data from MASSIVE, MSV000078555. Experiment: D120204_CoN_2207, file: D120204_MGH_2207_OGE07_rafkt_ft8dt_cc_01.mzml. Published as part of BMC Cancer. 2014 Jul 18;14(1):518 . From the Abstract: {{i}} We have used enrichment of extracellular matrix (ECM) from human patient samples and proteomics to de...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002460 | GPMDB
Resource Reanalysis 
TranscriptomicsGenome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis
We performed a genome-wide analysis of lncRNA expression to identify novel targets for the further study of liver metastasis in CRC. Samples obtained from CRC patients were analyzed using Arraystar human 8Ã?60K lncRNA/mRNA v3.0 microarrays chips to find differentially expressed lncRNAs and mRNAs; Th...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-75050 | biostudies-arrayexpress
TranscriptomicsGenomic Profile of Primary Colorectal Cancers and associated Liver Metastases
Comparison of genomic alterations of primary colorectal cancers with liver metastases of the same patient Keywords: array CGH, colorectal cancer, colon cancer, liver metastasis 21 primary colorectal cancers and 21 matched liver metastases hybridized against sex-matched control pools
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-10179 | biostudies-arrayexpress
TranscriptomicsGene expression signature for highly liver metastatic colon cancer cell line
The goal was to identify genes that promote liver metastasis of colorectal cancer. Microarray analysis was performed to compare gene expression and altered biological pathways between a poorly metastatic CT26 cell line as compared to an isogenic highly metastatic CT26 FL3 cell line that was isolated...
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-67675 | biostudies-arrayexpress
TranscriptomicscaArray_notte-00422: Molecular Dissection of Colon Cancer
RNA expression data was generated as part of a colon cancer study. Samples were obtained from patients, including primary colon cancer, polyps, metastases, and matched normal mucosa (obtained from the margins of the resection). The RNA was extracted from tissue samples obtained from resections and h...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-68468 | biostudies-arrayexpress
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