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ProteomicsCommon Repository of FBS Proteins (cRFP) to be added to a search database for mass spectrometric analysis of cell secretome
We propose to use cRFP (common Repository of FBS Proteins) in the MS (mass spectrometry) raw data search of cell secretome. cRFP is a small supplementary sequence list of high abundant fetal bovine serum proteins added to the reference database in use. The aim behind using cRFP is to prevent the con...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD015143 | Pride
Common repository of fbs proteins Database search Secretome 
ProteomicsComparison of serum-free cultivated HepG2 cells with cells cultivated under FBS containing conditions using proteomic analysis
With an increasing focus in science, politics and society on animal welfare, human in vitro systems are gaining particular interest as potential replacement tools for animal experimentation. However, animal components are still commonly used in cell culture models, thereby compromising the true pote...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD056319 | Pride
Human Hepg2 cells Fbs Serum-free 
ProteomicsConcentration and composition of the protein corona as a function of incubation time and serum concentration
We describe the concentration and composition of the protein corona as a function of incubation time (30 min and 1 day) and the concentration of fetal bovine serum (FBS) used to form the corona (5%, 10%, and 100%) on 200 nm carboxylate-modified magnetic NPs, using semi-automated processes.
ORGANISM(S): Bos taurus (Bovine) 
2023-03-21 | PXD035811 | Pride
Bovine Serum Magnetic nanoparticles Protein corona 
ProteomicsReverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
To determine the biological effects of MPS1 inhibition (both by siRNA and Drug (NMSP715)) on signaling pathways in GBM cells (U251 &U87), we profiled the modulation of phosphorylated and non-phosphorylated proteins using RPPA Relative protein levels for each sample were determined by interpolation o...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-67502 | biostudies-arrayexpress
ProteomicsProteomic profile of extracellular vesicles released by breast cancer cells
The objective of the experiment was to compare the proteomic profile of extracellular vesicles released by breast cancer cells in basal untreated condition (C1, C2, etc) or treated with the adipokine leptin (L1, L2 etc).
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037266 | Pride
Breast cancer Exosomes 
TranscriptomicsProstate Cancer Field Effect
In this study, comparison of gene expression profiles in benign epithelia from men with prostate cancer to those of men without prostate cancer reveal differences in several genes associated with prostate cancer. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used ...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-24171 | biostudies-arrayexpress
ProteomicsMulti-layered proteomic analysis for colorectal cancer
Matrix metalloproteinase-2 (MMP-2) plays a role in cell migration and invasion that involve degradation of extracellular matrix proteins as well as vascular remodeling. Increased expression of MMP-2 has often been observed in the tumors of colorectal cancer (CRC) patients. In order to unveil the per...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD018304 | Pride
Mmp-2 Silac Plasma Label-free Focal adhesion kinase Secretome Colorectal cancer 
ProteomicsMapping diversity in African trypanosomes using high resolution spatial proteomics
African trypanosomes are dixenous eukaryotic parasites that impose a significant human and veterinary disease burden on sub-Saharan Africa. Diversity between species and life-cycle stages is concomitant with distinct host and tissue tropisms within this group. Here, the spatial proteomes of two Afri...
ORGANISM(S): Trypanosoma brucei Trypanosoma congolense 
2023-10-22 | PXD035426 | Pride
Trypanosoma brucei Hyperlopit African trypanosomes Spatial proteome Parasite diversification Speciation Trypanosoma congolense Protein localisation 
ProteomicsThe Combination of Remdesivir and Ivermectin Exerts Highly Potent and Synergistic Antiviral Activity Against Murine Coronavirus and SARS-CoV-2 Infections
The COVID-19 pandemic highlighted the urgent need to develop effective and broad-spectrum antiviral therapies against coronaviruses. One strategy to address this concern is combination therapy using repurposed drugs against zoonotic viruses with pandemic potential. We previously demonstrated that th...
ORGANISM(S): Mus musculus (Mouse) Betacoronavirus 
2026-09-07 | PXD073706 | Pride
Remdesivir  ivermectin  combination therapy  repurposed drugs  murine hepatitis virus  proteomics  transcriptomics 
TranscriptomicsSingle-cell RNA-Sequencing of splenocytes from Four Core Genotype (FCG) mice
This repository contains single-cell gene expression profiling from mouse splenocytes of the Four Core Genotypes cross. By crossing mice with both a deletion of the sex-determining factor Sry on the Y-chromosome and a transgenic insertion of Sry on Chromosome 3 , four combinations of gonadal (testis...
ORGANISM(S): Mus musculus 
2024-10-14 | E-MTAB-13586 | biostudies-arrayexpress
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