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ProteomicsCompetitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound
With the idea of exploiting metal-templated reactions to achieve selective modification of cysteines in proteins for antibacterial applications, an organometallic cyclometalated Au(III) compound was explored in a competitive chemoproteomic approach based on the isoDTB-ABPP (isotopically labelled des...
ORGANISM(S): Staphylococcus aureus 
2022-04-19 | PXD031708 | Pride
Covalent inhibitors Organogold Competitive residue-specific proteomics Antibiotics 
ProteomicsProteome-wide profiling of the selectivity of diverse electrophiles (part 2)
Targeted covalent inhibitors (TCIs) are established as powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine. Competitive, residue-specific proteomics has been instrumental to streamline covalent drug discovery targeting cysteine. Several pr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2025-08-04 | PXD065811 | Pride
Human Chemical proteomics S. aureus 
ProteomicsProteome-wide profiling of the selectivity of diverse electrophiles
Targeted covalent inhibitors (TCIs) are established as powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine. Competitive, residue-specific proteomics has been instrumental to streamline covalent drug discovery targeting cysteine. Several pr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2025-08-09 | PXD024454 | Pride
Covalent inhibitors Chemical proteomics Activity-based protein profiling Isodtb-abpp 
UnknownHarnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes.
Not available
S-EPMC9093059 | biostudies-literature
UnknownProfiling the proteome-wide selectivity of diverse electrophiles.
Not available
S-EPMC12580327 | biostudies-literature
UnknownSmall-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Not available
S-EPMC7530896 | biostudies-literature
ProteomicsMAPK Pathway Inhibition Reshapes Kinase Chemoproteomic Ligandability Reporting on Cellular Activation States
Despite the pivotal role of oncogenic kinases in cancer initiation, progression, and resistance, functional profiling of their conformational states within cells remains challenging. Current methodologies often struggle to capture the dynamic structural features and inhibitor-bound conformations of ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD063040 | Pride
Ia-alkyne Tmt Braf Trametinib Chemoproteomics Mass spectrometry Mek1/2 Vemurafenib Arsq-alkyne Cysteine and lysine ligandability Abpp Click chemistry 
ProteomicsSmall-Molecule Activity-Based Probe for Monitoring Ubiquitin 2 C‑Terminal Hydrolase (UCHL1) Activity in Live Cells and Zebrafish 3 Embryos
Many reagents have emerged to study the function of specific enzymes in vitro. On the other hand, target specific reagents are scarce or need improvement, allowing investigations of the function of individual enzymes in their native cellular context. Here we report the development of a target-select...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD021557 | Pride
Orbitrap Human 
UnknownThe roles of phosphorylation and SHAGGY-like protein kinases in geminivirus C4 protein induced hyperplasia.
Not available
S-EPMC4376871 | biostudies-literature
UnknownPhosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.
Not available
S-EPMC3642088 | biostudies-literature
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