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MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
TranscriptomicsCis-encoded sRNAs repress expression of polysaccharide utilization loci in Bacteroides fragilis 638R
The phylum Bacteroidetes is a major component of the human gut microbiota which has a broad impact on the development and physiology of its host, and a potential role in a wide range of disease syndromes1-3. The predominance of Bacteroidetes and the genus Bacteroides in the distal gut is due in larg...
ORGANISM(S): Bacteroides fragilis 638R 
2016-07-22 | E-GEOD-73107 | biostudies-arrayexpress
TranscriptomicsGrowth of B. thetaiotaomicron on purified host mucosal glycans and glycan fragments
Bacteroides thetaiotaomicron was grown and transcriptionally profiled on a number of different host mucosal glycans and their component mono- and disaccharides. Experiments are performed in biological duplicate (2 replicates per growth condition). All cultures were harvested at similar points in mid...
ORGANISM(S): Bacteroides thetaiotaomicron 
2008-11-20 | E-GEOD-11962 | biostudies-arrayexpress
ProteomicsPNGaseF-generated N-glycans adduct onto peptides in the gas phase
Glycoproteomics has recently increased in popularity due to instrumental and methodological advances. That said, O-glycoproteomic analysis is still challenging for various reasons, including signal suppression and splitting, search algorithm limitations, and co-occupancy of N- and O-glycopeptides. T...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055856 | Pride
Adducts Glycoproteomics Mucinomics Pngasef Mass spectrometry N-glycans 
ProteomicsSite-specific profiling of structure and function of IgM B cell receptor glycans
Although N-linked glycans play pivotal roles in the regulation of antibody effector functions, little is known about the composition and functional impact of glycans expressed by human B cell receptors (BCRs), likely due to technical challenges. Here, we describe the site-specific glycosylation prof...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD062559 | Pride
Igm Primary naïve and memory b cells N-linked glycosylation Human b cell receptors 
TranscriptomicsDepolymerization of plant cell wall glycans by symbiotic human gut bacteria (Bacteroides ovatus)
Symbiotic bacteria inhabiting the distal human gut have evolved under intense pressure to utilize complex carbohydrates, predominantly plant cell wall glycans abundant in our diets. These substrates are recalcitrant to depolymerization by digestive enzymes encoded in the human genome, but are effici...
ORGANISM(S): Bacteroides ovatus 
2011-05-01 | E-GEOD-25575 | biostudies-arrayexpress
TranscriptomicsDepolymerization of plant cell wall glycans by symbiotic human gut bacteria (Bacteroides thetaiotaomicron)
Symbiotic bacteria inhabiting the distal human gut have evolved under intense pressure to utilize complex carbohydrates, predominantly plant cell wall glycans abundant in our diets. These substrates are recalcitrant to depolymerization by digestive enzymes encoded in the human genome, but are effici...
ORGANISM(S): Bacteroides thetaiotaomicron 
2011-05-01 | E-GEOD-25572 | biostudies-arrayexpress
UnknownStreamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy.
Not available
S-EPMC6347513 | biostudies-literature
TranscriptomicsGlycan effect on Saccharolytic Human Distal Gut Symbiont, B. thetaiotaomicron
This SuperSeries is composed of the following subset Series: GSE11944: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont GSE11953: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont: ECF ...
ORGANISM(S): Bacteroides thetaiotaomicron 
2008-11-20 | E-GEOD-11980 | biostudies-arrayexpress
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