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MetabolomicsDetermination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets
Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds to thousands of metabolites in biological systems. One major challenge in MSI is the annotation of m/z values, which is substantially complicated by background ions introduced throughout the c...
2021-06-15 | MTBLS954 | MetaboLights
MetabolomicsToxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The presen...
2023-10-10 | MTBLS1481 | MetaboLights
GenomicsEffects of DNA adducts on nanopore sequencing
Effects of DNA adducts on nanopore sequencing
PRJEB101972 | ENA
GenomicsRole of Isolevuglandin adducts as activators of TLR7 activity
Role of Isolevuglandin adducts as activators of TLR7 activity
PRJNA1330838 | ENA
GenomicsBase-resolution analysis of cisplatin-DNA adducts at the genome scale
Base-resolution analysis of cisplatin-DNA adducts at the genome scale
PRJNA330713 | ENA
ProteomicsThe Pathogenic Role of Novel Anti-malondialdehyde Modified-peptide Adduct Autoantibodies in Plasma and Importing Machine Learning for Predicting Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus
The goals of this study will valid and investigate levels of MDA, MDA-modified protein, and MDA-modified peptide adducts and their autoantibody isotypes.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD046723 | Pride
Coronary artery stenosis Plasma Coronary artery disease in patients with type 2 diabetes mellitus Malondialdehyde Autoantibody isotypes 
ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
GenomicsNucleobase adducts bind MR1 and stimulate MR1-restricted T cells
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells
PRJNA673154 | ENA
GenomicsMethylglyoxal-derived nucleoside adducts drive vascular dysfunction in a RAGE-dependent manner
Methylglyoxal-derived nucleoside adducts drive vascular dysfunction in a RAGE-dependent manner
PRJNA1055005 | ENA
GenomicsRNA-sequencing data of mouse macrophages exposed to polyphenols or polyphenol-amino acid adducts
RNA-sequencing data of mouse macrophages exposed to polyphenols or polyphenol-amino acid adducts
PRJNA851264 | ENA
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