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UnknownJUMPptm: Integrated software for sensitive identification of post-translational modifications and its application in Alzheimer's disease study.
Not available
S-EPMC9957936 | biostudies-literature
UnknownDiscovery of Post-Translational Modifications in Emiliania huxleyi.
Not available
S-EPMC8038017 | biostudies-literature
ProteomicsDiscovery and visualization of uncharacterized drug-protein adducts using mass spectrometry
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-24 | PXD025019 | Pride
Magnum Raloxifene Dicloxacillin Adduct Plasma Cyp3a4 Open search Metamorpheus Comet Human serum albumin Msfragger Penicillin Moda Hsa Xenobiotic Reactive metabolite P450-reductase Flucloxacillin Open-pfind Comet-ptm Limelight 
UnknownAPOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm.
Not available
S-EPMC6562066 | biostudies-literature
ProteomicsTime-course of ischemia-reperfusion in a pig model
We have performed an unbiased, open-search analysis of the oxidative PTMs and quantitative multiplexed proteomics that take place in the pig ischemic heart tissue during the first 24h after I/R. We used 40 castrated male Large-White pigs weighing 30 to 40 kg. Closed-chest 40 min I/R was performed i...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-05-24 | PXD045771 | Pride
Ptms Ischemic heart tissue Ischemia reperfusion (i/r) Quantitative proteomics Pig 
ProteomicsNeutrophil depletion experiment in ischemia reperfusion mouse model
To elucidate the role of neutrophils in the molecular alterations observed after I/R, we performed an experiment of I/R in neutrophil-depleted mice. Neutrophil depletion was performed by anti-Ly6G injection and IgG was used as vehicle. We have performed an unbiased, open-search analysis of the oxida...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045756 | Pride
Ischemia reperfusion Mouse Heart tissue Quantitative proteomics 
ProteomicsTime-course of ischemia-reperfusion in a mouse model
We have performed an unbiased, open-search analysis of the oxidative PTMs and quantitative multiplexed proteomics that take place in the mouse heart tissue during the first 48h after I/R. Surgically-induced MI was performed and animals were sacrificed at 10 min, 20 min, 40 min, 80 min, 2 hours, 6 ho...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045759 | Pride
Ptms Mouse Ischemia reperfusion (i/r) Heart tissue Quantitative proteomics 
ProteomicsLC-MS of Craniofacial cartilage organoids from ESCs
Knowledge of cell signaling pathways that drive human neural crest differentiation into craniofacial chondrocytes is incomplete, yet essential for using stem cells to regenerate craniomaxillofacial structures. To accelerate translational progress, we developed a differentiation protocol that generat...
ORGANISM(S): Homo sapiens (Human) 
2024-04-04 | PXD050668 | Pride
Lc-ms Ncsc Craniofacial organoids 
ProteomicsA meta-analysis of phosphoproteomics datasets from Toxoplasma gondii
We performed a meta-analysis over 10 publicly available phosphoproteomics datasets available for Toxoplasma gondii, as part of the PTMeXchange project using standardised analysis pipelines. For the reference genome ME49, in total, 24360 phosphosites were identified at a minimum of 5% FLR in any data...
ORGANISM(S): Toxoplasma gondii 
2026-06-09 | PXD078724 | Pride
Phosphoproteomics Ptmexchange Reanalysis Public data Flr 
ProteomicsAn AI-ready phosphorylation meta-analysis for Saccharomyces cerevisiae.
We, the PTMeXchange Consortium, present a meta-analysis of eight high-quality data sets to map 56,694 phosphosites in brewer's yeast (Saccharomyces cerevisiae) using strict control for false identifications. Each site has been classified into the Gold-Silver-Bronze (GSB) categories depending on the ...
ORGANISM(S): Saccharomyces cerevisiae 
2025-12-16 | PXD071918 | Pride
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