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MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
ProteomicsOVA N-glycans PGC-LC-MSMS - Large-scale identification and visualization of N-glycans with primary structures using GlySeeker
With PNGase F digestion, PGC enrichment,OVA N-glycans were analyzed using PGC nanoLC-ESI-MS/MS.Datasets were analyzed by the N-glycan database search engine called GlycanGoggle developed in our group.
ORGANISM(S): Gallus gallus (Chicken) 
2019-01-17 | PXD006400 | Pride
Pgc-lc-msms Ova N-glycans 
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
ProteomicsLC-MS/MS Isomeric Profiling of N-Glycans derived from Low-Abundant Serum Glycoproteins in Mild Cognitive Im-pairment Patients
Mild cognitive impairment (MCI) is an early stage of memory loss that affects cognitive abilities, such as language or virtual/spatial comprehension. This cognitive decline is mostly ob-served with the aging of individuals. Recently, MCI has been considered as a prodromal phase of Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036704 | Pride
Mci Biomarker glycan Neurological disorder Isomeric n-glycans 
ProteomicsRaider of the lost N glycans – Localizing rare, easily overlooked IgG N glycans with sulfation or bisecting LacNAc
Immunoglobulin G (IgG) is the most abundant immunoglobulin in human blood. Here it plays a central role in the immune system by recognizing antigens and mediating effector functions of the humoral immune defense. The role of IgG N glycosylation in many of these processes is well known. However, low ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-19 | PXD065180 | Pride
N glycans Igg 
ProteomicsPNGaseF-generated N-glycans adduct onto peptides in the gas phase
Glycoproteomics has recently increased in popularity due to instrumental and methodological advances. That said, O-glycoproteomic analysis is still challenging for various reasons, including signal suppression and splitting, search algorithm limitations, and co-occupancy of N- and O-glycopeptides. T...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055856 | Pride
Adducts Glycoproteomics Mucinomics Pngasef Mass spectrometry N-glycans 
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
ProteomicsSolid-phase extraction of N-linked glycans and glycosite-containing peptides (NGAG) for comprehensive characterization of glycoproteins
A novel chemoenzymatic method termed solid phase extraction of N-linked Glycans And Glycosite-containing peptides (NGAG) for the simultaneous analysis of N-glycans, glycosite-containing peptides, and intact N-glycopeptides with site-specific glycosylation information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080840 | MassIVE
ProteomicsIn-house packed porous graphitic carbon columns for liquid chromatography-mass spectrometry analysis of N-glycans
Although many reversed and normal stationary phases have been utilised for the separation of N-glycans, porous graphitic carbon (PGC) chromatography has become desirable because of its higher resolving capability, but is difficult to implement in a robust and reproducible manner. Herein, we demonstr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-07-08 | PXD024489 | Pride
Hypercarb Mass spectrometry Pgc Liquid chromatography N-glycan Porous graphitic carbon Lcmsn-glycan 
ProteomicsSolid-phase extraction of N-linked glycans and glycosite-containing peptides (NGAG) for comprehensive characterization of glycoproteins
A novel chemoenzymatic method termed solid phase extraction of N-linked Glycans And Glycosite-containing peptides (NGAG) for the simultaneous analysis of N-glycans, glycosite-containing peptides, and intact N-glycopeptides with site-specific glycosylation information.
ORGANISM(S): Homo sapiens (Human) 
2015-11-23 | PXD001571 | Pride
Lc-msms Glycosylation Deglycopeptide Glycosites Speg Spegag 
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