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ProteomicsCryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
Ubiquitin modification regulates fundamental cellular processes by controlling protein stability and function. The ubiquitin ligase COP1, conserved from plants to humans, targets developmental transcription factors. COP1 can act on its own or be incorporated into CULLIN4–RING ligase (CRL4) complexes...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071633 | Pride
Human Cop1-det1 ubiquitin ligase Cx-ms 
TranscriptomicsTranscriptome analysis of dark-grown cop1 and cop1BBX22-GFPox plants
The proper accumulation of BBX22 mediated by COP1 is crucial for plants to maintain better growth fitness when growing in the dark environment as well as responding to seasonal changes in day-length. The constitutive-photomorphogenic development of the cop1 mutant is enhanced in cop1BBX22-GFPox pla...
ORGANISM(S): Arabidopsis thaliana 
2011-06-01 | E-GEOD-22983 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabodpsis seedings exposed to UV-B irradiation
Interaction of COP1 and UVR8, which regulate UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis thaliana
ORGANISM(S): Arabidopsis thaliana 
2009-12-01 | E-MEXP-1957 | biostudies-arrayexpress
ProteomicsLight regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis
Intron retention (IR) is the most common alternative splicing (AS) event in Arabidopsis. Increasing studies have demonstrated a major role of IR in gene expression regulation. The impacts of IR on plant growth and development, and response to environments remains under explored. Here, we found that ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-20 | PXD043190 | Pride
Dcs proteins Arabidopsis Spliceosome Cop1 
TranscriptomicsExpression data from LNCap cell line treated with COP1 (RFWD2), ETV1, and JUN siRNAs
The proto-oncogenes ETV1, ETV4, and ETV5 encode members of the E26 transformation-specific (ETS) transcription factor family, which includes the most frequently rearranged and overexpressed genes in prostate cancer. Despite being critical regulators of development, little is known about their post-...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-27914 | biostudies-arrayexpress
GenomicsAcidithiobacillus ferrooxidans strain:COP1
Acidithiobacillus ferrooxidans strain:COP1 Genome sequencing and assembly
PRJNA623639 | ENA
TranscriptomicsTranscription profiling of Arabidopsis wild type, cop1-4, hy5-1 mutant seedlings exposed to polychromatic radiation
Seven-day-old white-light-grown wild-type, cop1-4 or hy5-1 mutant Arabidopsis seedlings were exposed for fifteen minutes to polychromatic radiation with decreasing short-wave cut-off in the UV range (WG305 = +UV-B, WG327 = -UV-B) and samples were taken 1 h after the onset of irradiation.
ORGANISM(S): Arabidopsis thaliana 
2006-08-16 | E-MEXP-557 | biostudies-arrayexpress
TranscriptomicsCOP1 siRNA knockdown in human Hepatocellular carcinoma cells
Development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. We have previously demonstrated that constitutively photomorphogenic 1 (COP1), which regulates p53 activity by ubiquitination, is frequently overexpressed in human HCC. Here we examined whether molecul...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-21955 | biostudies-arrayexpress
GenomicsUbiquitin ligase COP1 suppresses microglia-mediated inflammation
Ubiquitin ligase COP1 suppresses microglia-mediated inflammation
PRJNA607249 | ENA
GenomicsKinetics of LPS induction in wt and Cop1-ko BMDMs
Kinetics of LPS induction in wt and Cop1-ko BMDMs
PRJNA472582 | ENA
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