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TranscriptomicsThe COP9 signalosome mediates transcriptional and metabolic response during fungal development
The COP9 signalosome complex (CSN) is a crucial regulator of ubiquitin ligases. Defects in CSN result in embryonic impairment and death in higher eukaryotes, whereas the filamentous fungus Aspergillus nidulans survives without CSN, but is unable to complete sexual development. We investigated overal...
ORGANISM(S): Emericella nidulans 
2010-09-09 | E-GEOD-22442 | biostudies-arrayexpress
ProteomicsStructural analysis of the CSN complex to understand its inhibition mechanism
We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, cross-linking mass spectrometry, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and str...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD063786 | Pride
Csn Quantitative ms Crls Protein ubiquitination Neddylation Xl-ms Cryo-em Cop9 signalsome 
ProteomicsStructural analysis of the CSN complex to understand its inhibition mechanism
We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and structural changes of the CSN comple...
ORGANISM(S): Homo sapiens (Human) 
2025-11-22 | PXD063822 | Pride
Csn Quantitative ms Crls Protein ubiquitination Neddylation Cryo-em Cop9 signalsome 
UnknownOsJAB1 Positively Regulates Ascorbate Biosynthesis and Negatively Regulates Salt Tolerance Due to Inhibiting Early-Stage Salt-Induced ROS Accumulation in Rice.
Not available
S-EPMC10675544 | biostudies-literature
GenomicsComprehensive Genomic Characterization of Refractory Multiple Myeloma Reveals a Complex Mutational and Structural Landscape Associated with Drug Resistance (H067)
Outcome of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) is still very poor. To elucidate the genetic landscape of relapsed/refractory MM (RRMM) we performed whole genome and transcriptome sequencing of 39 heavily pretreated RRMM pa...
EGAS00001004363 | EGA
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