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ProteomicsSpatial omics of acute myocardial infarction reveals a novel mode of immune cell infiltration
Myocardial infarction (MI) continues to be a leading cause of death worldwide. Even though it is well-established that the complex interplay between different cell types determines the overall healing response after MI, the precise changes in the tissue architecture are still poorly understood. Here...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-16 | PXD066993 | Pride
Human Infarction Spatial proteomics Lc-ms Heart Myocardial 
ProteomicsDeep visual proteomics uncovers nociceptor diversity and pain targets
The richness of our somatosensory experience is reflected in the functional diversity of somatic sensory neurons. Single-cell sequencing (scRNA) of sensory neurons has revealed a molecular basis for such diversity1–3. However, sensory neuron diversity has yet to be captured at the level of the prote...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD070495 | Pride
ProteomicsSpatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets
High-grade serous ovarian cancer (HGSOC) is often detected at an advanced stage, where curative treatment options are limited. Recent advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover molecular drivers of early tumorigenesis and novel...
ORGANISM(S): Homo sapiens (Human) 
2025-10-19 | PXD069630 | Pride
Stic Fallopian tube Ovarian cancer 
UnknownAn interphase actin wave promotes mitochondrial content mixing and organelle homeostasis.
Not available
S-EPMC11076292 | biostudies-literature
UnknownCryo-EM structure of the full-length Lon protease from Thermus thermophilus.
Not available
S-EPMC8835725 | biostudies-literature
UnknownA glance at post-translational modifications of human thyroglobulin: potential impact on function and pathogenesis.
Not available
S-EPMC9254275 | biostudies-literature
ProteomicsAn interphase actin wave promotes mitochondrial content mixing and 2 organelle homeostasis
Across the cell cycle, mitochondrial dynamics are regulated by a cycling wave of actin polymerization/depolymerization. In metaphase, this wave induces the assembly of actin comet tails on mitochondria that propel these organelles to drive spatial mixing,resulting in their equitable inheritance by d...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050085 | Pride
Fmnl1 Actin Mitochondrial fission Homeostasis 
ProteomicsK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Conjugation of ubiquitin (Ub) to numerous substrate proteins regulates virtually all cellular processes. Eight distinct ubiquitin polymer linkages specifying different functional outcomes are generated in cells. However, the roles of some atypical poly-ubiquitin topologies, in particular linkages vi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD023579 | Pride
Ubiquitin Proteomics K27 
UnknownFine-scale seascape genomics of an exploited marine species, the common cockle Cerastoderma edule, using a multimodelling approach.
Not available
S-EPMC7463313 | biostudies-literature
ProteomicsA streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Formalin fixation and paraffin-embedding (FFPE) is the most common method to preserve human tissue for clinical diagnosis and FFPE archives represent an invaluable resource for biomedical research. Proteins in FFPE material are stable over decades but their efficient extraction and streamlined analy...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD017269 | Pride
Biobank Ffpe Cancer Proteomics Tissue Mass spectrometry Protocol 
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