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ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Summary Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumo...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD047451 | Pride
Cprc1 H3k27me3 Pcgf4 H3k27m Cbx4 Diffuse midline glioma 
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumour cells...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD058532 | Pride
Interaction proteomics 
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in H3K27M-mutant diffuse midline glioma.
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting the enzymatic activity of the complex. Paradoxically, PRC2 histone methyltran...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD047401 | Pride
Glioma Epigenetics Prc2 
GenomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
PRJNA1035121 | ENA
UnknownParallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells.
Not available
S-EPMC7112768 | biostudies-literature
TranscriptomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumour cells...
ORGANISM(S): Homo sapiens 
2025-05-28 | GSE246931 | GEO
GenomicsAedes aegypti isolate:CPRC1
Complete genome sequences of Aedes aegypti collected from Tamil Nadu, India
PRJNA637814 | ENA
GenomicsParallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
PRJNA562733 | ENA
GenomicsCell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation [scRNA-Seq]
Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation [scRNA-Seq]
PRJNA865370 | ENA
GenomicsCell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation [RNA-seq]
Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation [RNA-seq]
PRJNA918373 | ENA
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