Sort   by:  
 Page size 
GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Summary Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumo...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD047451 | Pride
Cprc1 H3k27me3 Pcgf4 H3k27m Cbx4 Diffuse midline glioma 
GenomicsNon-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis
Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here we find that the non-canonical PRC1.1 complex, as identified by mass spectrometry-based proteomics, is critically important for human leukemic stem cells. D...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-54580 | biostudies-arrayexpress
TranscriptomicsRNA seq of intrahepatic cholangiocarcinoma cell lines and normal bile duct epithelial cells
Our data uncovered the functional heterogeneity of CAFs during ICC metastasis and set the epigenetic regulator PCGF4 as the crucial effector
ORGANISM(S): Homo sapiens 
2023-09-04 | GSE241923 | GEO
TranscriptomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumour cells...
ORGANISM(S): Homo sapiens 
2025-05-28 | GSE246931 | GEO
ProteomicsRNF2_PCGF4_CBX8 crosslinked with BS3
Recombinant PRC1 complex consisting of RNF2, PCGF4 and CBX8 was crosslinked with BS3 to identify complex structure
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD049094 | Pride
Xl-ms Prc1 Cbx8 Polycomb 
TranscriptomicsTranscription profiling of brain and gut neurospheres of wild type and Bmi-1 knockout mice to reveal that Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
The cRNA derived from Brain and Gut neurospheres of wild type and BMI-1 knockout mice were hybridized to Affymetrix mouse ver 2 Chips A, B and C. In case of brain neurospheres, the cRNA were generated by one round RNA amplification (conventional method). In contrast, the cRNA of Gut neurospheres wer...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-611 | biostudies-arrayexpress
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumour cells...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD058532 | Pride
Interaction proteomics 
UnknownStructure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Not available
S-EPMC4003909 | biostudies-literature
TranscriptomicsThe expression level of microRNA after knockdown of Twist1 or Bmi1
To screen the microRNA regulated by Twist1 and Bmi1 Establish stable transfectants of pSUPER-sh-Twist1 or pSUPER-sh-Bmi1 in OECM1 cells and analyze the miRNA expression level of by microRNA microarray. OECM1 transfected with pSUPER-sh-scr was used as a control experiment.
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-29586 | biostudies-arrayexpress
Sort   by:  
 Page size