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MetabolomicsNMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

2020-11-19 | MTBLS563 | MetaboLights
TranscriptomicsCritically ill patients with either gram-positive sepsis or gram-negative sepsis
Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A pros...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-6535 | biostudies-arrayexpress
ProteomicsKetogenic diet versus standard high-carbohydrate nutrition in sepsis: a randomized controlled trial
Rationale: Sepsis patients suffer from severe metabolic and immunologic dysfunction that may be amplified by standard carbohydrate-based nutritional regimes. We therefore hypothesize that a ketogenic diet improves sepsis treatment. Objectives: We investigated the safety and feasibility of a ketogeni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD046061 | Pride
Nutritional medicine Inflammation Sepsis Intensive care Critically ill patients Ketogenic diet 
GenomicsTime series gene expression in critically ill patients: PREVAIL study
Time series gene expression in critically ill patients: PREVAIL study
PRJNA486363 | ENA
TranscriptomicsTranscriptomic analysis reveals abnormal repair and remodeling in survivors of critical illness with sustained muscle weakness
ICU acquired weakness (ICUAW) is a complication of critical illness characterized by structural and functional impairment of skeletal muscle that may persist for years after ICU discharge with many survivors developing protracted courses with few regaining functional independence. Elucidating molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78929 | biostudies-arrayexpress
GenomicsTranscriptional Profiling of Leukocytes in Critically Ill COVID19 Patients
Transcriptional Profiling of Leukocytes in Critically Ill COVID19 Patients
PRJNA648120 | ENA
GenomicsWhole transcriptome analysis of critically ill elderly patients with sepsis
Whole transcriptome analysis of critically ill elderly patients with sepsis
PRJNA896158 | ENA
ProteomicsSerum H-ferritin to Ferritin ratio as a biomarker of HLH in critically ill patients with hyperferritinemia
Ferritin is a sensitive screening parameter to diagnose hemophagocytic lymphohistiocytosis in critically ill patients but lacks specificity. Ferritin is composed of 24 subunits with 2 types of peptide chains: light (FeL) or heavy (FeH). The proportion of H subunit is suggested to increase during hyp...
ORGANISM(S): Homo sapiens (Human) 
2026-03-06 | PXD065102 | Pride
Lc-msms Human Ferritin Serum 
GenomicsTranscriptomic clustering of critically-ill COVID-19 patients [Day 4 RNAseq]
Transcriptomic clustering of critically-ill COVID-19 patients [Day 4 RNAseq]
PRJNA849923 | ENA
TranscriptomicsGenome-wide blood transcriptional profiling in critically ill patients - MARS consortium
The host response in critically ill patients with sepsis, septic shock remains poorly defined. Considerable research has been conducted to accurately distinguish patients with sepsis from those with non-infectious causes of disease. Technological innovations have positioned systems biology at the fo...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-65682 | biostudies-arrayexpress
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