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ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of ubiquitin-rbx1 crosslinks
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049047 | Pride
Ubiquitin Photocrosslinking Crl2vhl Rbx1 
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - verification of ubiquitin UBE2R1 (C93K) loading assay
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049050 | Pride
Structural Mimetic Ube2r1 Ubiquitin E2 
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of BRD4 ubiquitination sites
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049043 | Pride
Protac Mz1 Ubiquitin Crl2vhl Brd4 
GenomicsCIDR: Collaborative Study on the Genetics of Alcoholism Case Control Study

This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on ...

phs000125.v1.p1 | EGA
GenomicsStudy of Addiction: Genetics and Environment (SAGE)

This study is part of the Gene Environment Association Studies initiative (GENEVA) funded by the National Human Genome Research Institute. The overarching goal is to identify novel genetic factors that contribute to addiction through a large-scale genome-wide association study of DSM-IV alcoh...

phs000092.v1.p1 | EGA
UnknownSix-Year Results From RELEVANCE: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma.
Not available
S-EPMC9553375 | biostudies-literature
GenomicThe Collaborative Study on the Genetics of Alcoholism (COGA)

COGA is a family study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on study particip...

phs000763 | dbGaP
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