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TranscriptomicsRNA sequencing comparing SCN CSF3R-d715 RUNX1-D171N (RHD) treated with the HDAC inhibitor MS275, octyl-(R)-2hydroxyglutarate (2HG) or solvent control (DMSO)
Effects of TET2 on repressing inflammation have been assigned to its methylcytosine dioxygenase activity, but also to its ability to recruit HDAC-mediated repressor activity to pro-inflammatory genes. To discriminate between the two above-proposed functions of TET2, we asked how inhibition of its en...
ORGANISM(S): Homo sapiens 
2020-08-24 | E-MTAB-9374 | biostudies-arrayexpress
TranscriptomicsThe RNA-binding protein HuR coordinates global changes in gene expression during patterning of early peripheral nerves
Identify mRNA targets of the RNA-binding protein HuR in vivo during Schwann cell development using RIP-chip analysis. IP protocol of endogenous mRNA-transfected HuR complexes was performed as described in Keene et al. (2006). In brief, 500 mg of whole-cell lysate obtained from a pool of NB or P5 sci...
ORGANISM(S): Mus musculus 
2012-01-19 | E-MEXP-3519 | biostudies-arrayexpress
TranscriptomicsTemporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R
Precise spatiotemporal control of mRNA translation machinery is essential to proper development of highly complex systems like the neocortex. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a deve...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-50809 | biostudies-arrayexpress
TranscriptomicsRNA-seq of RNase R treated poly(A)-/ribo- RNAs from H9 cells
We have used RNA-seq to examine circular RNAs from RNase R treated poly(A)-/ribo- RNAs in human embryonic stem cells Examine circular RNAs in human embryonic stem cells
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48003 | biostudies-arrayexpress
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to Chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD022467 | Pride
Proteomics Hnrnpr Ip Ftld Als Motoneurons Dna damage response 
UnknownTrackplot: a fast and lightweight R script for epigenomic enrichment plots.
Not available
S-EPMC10932608 | biostudies-literature
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 2
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19382 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 1
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19381 | biostudies-arrayexpress
TranscriptomicsCumulus cells genetic profile of patients stimulated with r-hLH or hCG evaluated with MicroArray analysis versus r-hFSH stimulated COCs
The aim of this study was to evaluate if different ovaric stimulation protocols modify gene expression profiles in COCs of infertile women. mRNA pools in COCs are essential for correct meiosis and activation of oocyte during fecondation and their alterations lead to reduced differentiation and oocyt...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-35228 | biostudies-arrayexpress
UnknownDDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops.
Not available
S-EPMC10066596 | biostudies-literature
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