Sort   by:  
 Page size 
ProteomicsStructural analysis of the CSN complex to understand its inhibition mechanism
We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, cross-linking mass spectrometry, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and str...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD063786 | Pride
Csn Quantitative ms Crls Protein ubiquitination Neddylation Xl-ms Cryo-em Cop9 signalsome 
TranscriptomicsPost-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
The COP9 signalosome (CSN) is a conserved protein complex occurring in all eukaryotes. The mammalian CSN consists of eight subunits (CSN1 – CSN8) and possesses an intrinsic metalloprotease JAMM motif localised to CSN5. In addition, it is associated with kinases such as protein kinase CK2 and D and t...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-19085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) COP9 signalosome (csn) mutant analysis
Transcript profiling analysis of csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) light grown and dark grown mutant seedlings compared to light grown and dark grown wild type using Arabidopsis ATH1 GeneChip array Experiment Overall Design: We compare eight samples of 7 day-old light grown or dark grown csn3-...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-9728 | biostudies-arrayexpress
ProteomicsFungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase
The eight-subunit COP9 signalosome (CSN complex), controls the exchange of E3 ubiquitin cullin RING ligase receptors through its deneddylase activity, providing specificity to eukaryotic protein degradation. The conserved eight-subunit CSN complex is required for multicellular development of the fil...
ORGANISM(S): Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 
2023-08-10 | PXD043205 | Pride
Cop9 signalosome Aspergillus nidulans Gfp-affinity purifications Csn complex Native complex assembly Subcomplexes 
ProteomicsMass spec results of CSN-FBP project
This project amis to elucidate the mechanism by which CSN regulates the assembly of SCF complex.
ORGANISM(S): Arabidopsis Thaliana 
2023-12-05 | PXD047481 |
ProteomicsIntegrative Structural Characterization of the Human Canonical and Non-canonical Cop9 Signalosome Complexes
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that functions as a deneddylase to inactivate Cullin-RING E3 ligases for controlling protein ubiquitination. CSN possesses structural flexibility that is important for its activation upon binding to a diverse array of CRLs. Th...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD014673 | Pride
Mass spectrometry Sulfoxided based cross-linkers Cross-linking Intergrative modeling platform (imp) Ms-cleavable Cop9 signalosme 
ProteomicsStructural analysis of the CSN complex to understand its inhibition mechanism
We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and structural changes of the CSN comple...
ORGANISM(S): Homo sapiens (Human) 
2025-11-22 | PXD063822 | Pride
Csn Quantitative ms Crls Protein ubiquitination Neddylation Cryo-em Cop9 signalsome 
UnknownThe C-terminal tail of CSNAP attenuates the CSN complex.
Not available
S-EPMC10355216 | biostudies-literature
TranscriptomicsRole of CSN5 in breast cancer (siRNA transfections)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9204 | biostudies-arrayexpress
TranscriptomicsRole of CSN5 in breast cancer (array CGH)
CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanis...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9205 | biostudies-arrayexpress
Sort   by:  
 Page size