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TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants
High-throughput pyrosequencing of endogenous small RNAs from CSR-1 IP complexes and csr-1(tm892) and ego-1(om97) mutants with corresponding controls. RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CS...
ORGANISM(S): Caenorhabditis elegans 
2009-10-02 | E-GEOD-18165 | biostudies-arrayexpress
TranscriptomicsCSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
P granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate ...
ORGANISM(S): Caenorhabditis elegans 
2015-05-20 | E-GEOD-67954 | biostudies-arrayexpress
TranscriptomicsGlobal effects of the CSR-1 RNA interference pathway on transcriptional landscape
Argonaute proteins and their small RNA co-factors short interfering RNAs (siRNAs) are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) antisense to germline trans...
ORGANISM(S): Caenorhabditis elegans 
2014-02-28 | E-GEOD-49946 | biostudies-arrayexpress
ProteomicsTranslation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G-RNAs are produced remains unknown. Here, we show ...
ORGANISM(S): Caenorhabditis elegans 
2021-04-23 | PXD020293 | Pride
Csr-1 Argonaute C. elegans Small rna 
ProteomicsCSR-1A post-translational modification
CSR-1 is an essential Argonaute protein that binds to a subclass of 22G-RNAs targeting most germline-expressed genes. Here we show that the two isoforms of CSR-1 have distinct expression patterns; CSR-1B is ubiquitously expressed throughout the germline and during all stages of development while CSR...
ORGANISM(S): Caenorhabditis elegans 
2021-06-17 | PXD021227 | Pride
C. elegans Dimethylation Csr-1a 
GenomicsRegulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
PRJNA1072655 | ENA
GenomicsEffects of csr-1 knockdown on gene expression and mRNA splicing
Effects of csr-1 knockdown on gene expression and mRNA splicing
PRJNA1018651 | ENA
GenomicsRegulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
PRJNA1242266 | ENA
GenomicsRegulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
PRJNA1072654 | ENA
GenomicsRegulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans
PRJNA1072657 | ENA
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