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ProteomicsQuantitative accuracy and precision in multiplexed single-cell proteomics.
Multiplexed quantitative mass spectrometry-based proteomics is shaped by numerous opposing propositions. With the emergence of multiplexed single-cell proteomics, studies increasingly present single cell measurements in conjunction with an abundant congruent carrier to improve precursor selection an...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD027912 | Pride
Single-cell proteomics Benchmarking 
ProteomicsComparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition
Single cell transcriptomics have revolutionized fundamental understanding of basic biology and disease. Since transcripts often do not correlate with protein expression, it is paramount to complement transcriptomics approaches with proteome analysis at single cell resolution. Despite continuous tech...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-17 | PXD023574 | Pride
Dia-tmt Identification-independent Ultra-low input samples 
ProteomicsAn automated workflow for label-free and multiplexed single cell proteomics sample preparation at unprecedented sensitivity.
The analysis of single cell proteomes has recently become a viable complement to transcript and genomics studies. Proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Therefore, the global analysis of the proteome is essential to study cellula...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD025387 | Pride
Single cell proteomics Proteochip Label-free Multiplexed 
ProteomicsCardiac organoids reveal mechanisms of human cardiogenesis
Self-organisation and coordinated morphogenesis of multiple cardiac lineages is essential for the development and function of the heart1-3. However, the absence of a human in vitro model that mimics the basic lineage architecture of the heart hinders research into developmental mechanisms and congen...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD018306 | Pride
Cardiac organoids Cardiac in vitro differentiation Human pluripotent stem cells 
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