Sort   by:  
 Page size 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
ProteomicsActivity-based profiling of cullin-RING ligase networks by conformation-specific probes
The cullin-RING E3 ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like protein NEDD8. Assessing cellular repertoires of activated CRL complexes is critical for understanding eukaryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-02 | PXD039649 | Pride
Ligase Cullin Nedd8 Ring Ubiquitin E3 
UnknownCullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.
Not available
S-EPMC7205596 | biostudies-literature
UnknownNEDD8 and ubiquitin ligation by cullin-RING E3 ligases.
Not available
S-EPMC8096640 | biostudies-literature
UnknownSuramin inhibits cullin-RING E3 ubiquitin ligases.
Not available
S-EPMC4833235 | biostudies-literature
TranscriptomicsThe Hace1 E3 Ligase Modulates the Activity of Multiple Tumor Suppressive CRL E3 Ligases by binding to CAND1
The Hace1 E3 ligase is a tumor suppressor in stressed cells. Through unknown mechanisms, Hace1 indirectly targets the cyclin D1 proto-oncogene for proteasomal degradation during nutrient depletion. We now show that Hace1 targets HIF1alpha for VHL-dependent degradation during hypoxia. To better under...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-25452 | biostudies-arrayexpress
ProteomicsSupporting raw MS data for paper (doi:10.1038/s41589-025-01894-4) by Raiff A., Zhao Z. et al (2025), titled "TOM20-Driven E3 Ligase Recruitment Regulates Mitochondrial Dynamics Through PLD6"
Supporting raw MS data for paper (doi:10.1038/s41589-025-01894-4) by Raiff A., Zhao Z. et al (2025), titled "TOM20-Driven E3 Ligase Recruitment Regulates Mitochondrial Dynamics Through PLD6". Index of MS files and labels Supplementary Table 1 - HEK293T - Proteome (CZ-1-23 | Unimod:35; 737; 4 | 126 -...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095689 | MassIVE
UnknownFlexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination.
Not available
S-EPMC3220518 | biostudies-literature
ProteomicsDual BACH1 regulation by complementary SCF-type E3 ligases
BACH1, FBXO22, FBXL17, oxidative stress response, E3, Cullin-RING ligases, F-box, cysteine modification, S-nitrosylation, heme
ORGANISM(S): Homo sapiens (Human) 
2024-12-03 | PXD051074 | Pride
Fbxl17 S-nitrosylation Fbxo22 Heme Oxidative stress response Cullin-ring ligases Bach1 E3 Cysteine modification F-box 
UnknownProtein neddylation: beyond cullin-RING ligases.
Not available
S-EPMC5131867 | biostudies-literature
Sort   by:  
 Page size