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ProteomicsImmunoprecipitation followed by mass spectropmetry of Plasmodium falciparum Cullin2
This study is aim to characterize Plasmodium Cullin2 to find its interacting partners
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-02-14 | PXD040268 | Pride
Ip-ms Cullin2 Plasmodium 
TranscriptomicsThe tumor antigen PRAME is a substrate recognition subunit of a Cul2-based ubiquitin ligase and is associated with active NFY promoters
The human tumor antigen PRAME (Preferentially expressed antigen of melanoma) is frequently overexpressed in tumors. High PRAME levels correlate with poor clinical outcome of several cancers, but the mechanisms by which PRAME could be involved in tumorigenesis remain largely elusive. We applied prote...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-GEOD-26439 | biostudies-arrayexpress
ProteomicsLabel Free Quantitative mass spectropmetry of Plasmodium falciparum Cullin2 protein in wild type and knock down conditions
Label free quantification of PfCullin2 in wild type and knock down conditions were also performed to check differential regulation of biological pathways.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-02-14 | PXD040197 | Pride
Cullin2 Kd Lfq-ms Plasmoium Wt 
ProteomicsPramel7-Cul2 axis establishes ground-state gene expression in embryonic stem cells
Pluripotency is established in E4.5 preimplantation epiblast, the founder populations of the adult embryo. The establishment of in vitro models that closely resemble ground-state pluripotency represents an important opportunity to study early embryo development. Pramel7, a protein highly expressed i...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD032184 | Pride
Pluripotency Embryonic stem cells Pramel7 Proteasome Cullin 2 
UnknownMicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
Not available
S-EPMC10312157 | biostudies-literature
GenomicsThe tumor antigen PRAME is a substrate recognition subunit of a Cul2-based ubiquitin ligase and is associated with active NFY promoters
The human tumor antigen PRAME (Preferentially expressed antigen of melanoma) is frequently overexpressed in tumors. High PRAME levels correlate with poor clinical outcome of several cancers, but the mechanisms by which PRAME could be involved in tumorigenesis remain largely elusive. We applied prote...
ORGANISM(S): Homo sapiens 
2011-07-29 | GSE26439 | GEO
UnknownTumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the  receptor protein of CRL2Prame complex.
Not available
S-EPMC8184998 | biostudies-literature
UnknownElongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF.
Not available
S-EPMC11039524 | biostudies-literature
UnknownSurface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
Not available
S-EPMC6109845 | biostudies-literature
UnknownA functional artificial neural network for noninvasive pretreatment evaluation of glioblastoma patients.
Not available
S-EPMC8765794 | biostudies-literature
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