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ProteomicsZc3h10 is a novel mitochondrial regulator
Mitochondria are the energy-generating hubs of the cell. In spite of considerable advances, our understanding of the factors that regulate the molecular circuits that govern mitochondrial function remains incomplete. Using a genome-wide functional screen, we have identified the poorly characterized ...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD008833 | Pride
Zc3h10 Mitochondria Energy metabolism Oxidative phosphorylation. 
ProteomicsMapping of Functional SARS-CoV-2 Receptors in Human Lungs Establishes Differences in Variant Binding and SLC1A5 as a Viral Entry Modulator of hACE2
The COVID-19 pandemic is an infectious disease caused by SARS-CoV-2. The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (hACE2) receptors by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Although the molecular and structural bases of...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD038005 | Pride
Spike  super resolution microscopy  ace2 co-factors  rbd  viral binding  viral entry 
ProteomicsGeneration of drug-tolerant cells by lncRNAs downstream of osmotic stress
Environmental cues within the tumor microenvironment (TME) affect tumor heterogeneity and plasticity, ultimately influencing therapy responses. Recent studies have shown that cancer stem cell niches are located near blood vessels and thus may be exposed to abrupt changes in the osmotic conditions. H...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD060369 | Pride
Incrnas Cancer Dda 
ProteomicsProteomics Profiling of Arginine Methylation Defines PRMT5 Substarate Specificity
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation, an abundant post-translational modification occurring on both chromatin-bound and cytoplasmic proteins. Growing evidence supports the involvement of PRMT5, the major Type II PRMT, in pro-survival and differentiation pathways,...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD009070 | Pride
Lc-ms Prmt5 Arginine methylation 
ProteomicsRestrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory elements. The Restrictor complex, composed of the Pol II-interacting protein WDR82 and the RNA-binding protein ZC3H4, suppresses...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD043638 | Pride
Ranscription termination Zc3h4 
ProteomicsLipid nanoparticles improves ex vivo gene editing of human hematopoietic cells
Ex-vivo gene editing in T cells and hematopoietic stem/progenitor cells (HSPCs) holds promise for treating diseases by non-homologous end joining (NHEJ) gene disruption or homology-driven repair (HDR) gene correction. Gene editing encompasses delivery of nucleases by electroporation and, when aiming...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037529 | Pride
Hunan Nanoparticles Hematopoietic cells 
ProteomicsTBC1D22B Regulates ER-to-Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer
The anterograde secretory pathway shapes the extracellular environment and the ability of cells to communicate, through the release of cytokines, growth factors, enzymes and extracellular matrix components, and through the regulation of the composition of the plasma membrane (PM). The underlying mol...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD060457 | Pride
Tbc1d22b Rab1b Apex 
ProteomicsGTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Copy number variations at 7q11.23 cause neurodevelopmental disorders with shared and opposite manifestations. Deletion leads to Williams-Beuren syndrome (WBS), while duplication causes 7q11.23 microduplication syndrome (7Dup). Converging evidence indicates GTF2I, from the 7q11.23 locus, is a key me...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD036770 | Pride
Sociability Organoids Neurodevelopment Autism Gtf2i Transcriptomics 
ProteomicsFAM46C is an IFN stimulated gene that restricts lentiviral particle production by modulating autophagy
FAM46C is a multiple myeloma tumour suppressor whose function is only starting to be elucidated. We recently showed that in multiple myeloma cells FAM46C triggers apoptosis by inhibiting autophagy and altering intracellular trafficking and protein secretion. To date, both a physiological characteriz...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD036818 | Pride
Fam46c inhibits lentiviral production 
ProteomicsPlasma-derived Exosome-Like Vesicles (ELVs) of COVID-19 patients expose SARS-CoV-2-Spike-derived fragments and contribute to the adaptive immune response
COVID-19 is an infectious disease caused by beta-coronavirus SARS-CoV-2 which has rapidly spread across the globe starting from February 2020. It is well established that during viral infection extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding ex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029007 | Pride
Exosome-like vesicles (elvs) Covid-19 Lcmsms 
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