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ProteomicsZc3h10 is a novel mitochondrial regulator
Mitochondria are the energy-generating hubs of the cell. In spite of considerable advances, our understanding of the factors that regulate the molecular circuits that govern mitochondrial function remains incomplete. Using a genome-wide functional screen, we have identified the poorly characterized ...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD008833 | Pride
Zc3h10 Mitochondria Energy metabolism Oxidative phosphorylation. 
ProteomicsMapping of Functional SARS-CoV-2 Receptors in Human Lungs Establishes Differences in Variant Binding and SLC1A5 as a Viral Entry Modulator of hACE2
The COVID-19 pandemic is an infectious disease caused by SARS-CoV-2. The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (hACE2) receptors by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Although the molecular and structural bases of...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD038005 | Pride
Spike  super resolution microscopy  ace2 co-factors  rbd  viral binding  viral entry 
ProteomicsProteomics Profiling of Arginine Methylation Defines PRMT5 Substarate Specificity
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation, an abundant post-translational modification occurring on both chromatin-bound and cytoplasmic proteins. Growing evidence supports the involvement of PRMT5, the major Type II PRMT, in pro-survival and differentiation pathways,...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD009070 | Pride
Lc-ms Prmt5 Arginine methylation 
ProteomicsLipid nanoparticles improves ex vivo gene editing of human hematopoietic cells
Ex-vivo gene editing in T cells and hematopoietic stem/progenitor cells (HSPCs) holds promise for treating diseases by non-homologous end joining (NHEJ) gene disruption or homology-driven repair (HDR) gene correction. Gene editing encompasses delivery of nucleases by electroporation and, when aiming...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037529 | Pride
Hunan Nanoparticles Hematopoietic cells 
ProteomicsRestrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory elements. The Restrictor complex, composed of the Pol II-interacting protein WDR82 and the RNA-binding protein ZC3H4, suppresses...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD043638 | Pride
Ranscription termination Zc3h4 
ProteomicsGTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Copy number variations at 7q11.23 cause neurodevelopmental disorders with shared and opposite manifestations. Deletion leads to Williams-Beuren syndrome (WBS), while duplication causes 7q11.23 microduplication syndrome (7Dup). Converging evidence indicates GTF2I, from the 7q11.23 locus, is a key me...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD036770 | Pride
Sociability Organoids Neurodevelopment Autism Gtf2i Transcriptomics 
ProteomicsPlasma-derived Exosome-Like Vesicles (ELVs) of COVID-19 patients expose SARS-CoV-2-Spike-derived fragments and contribute to the adaptive immune response
COVID-19 is an infectious disease caused by beta-coronavirus SARS-CoV-2 which has rapidly spread across the globe starting from February 2020. It is well established that during viral infection extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding ex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029007 | Pride
Exosome-like vesicles (elvs) Covid-19 Lcmsms 
ProteomicsAcetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide
Histone modifying enzymes depend on the availability of cofactors, with acetyl-CoA being required for histone acetyltransferase (HAT) activity. The discovery that mitochondrial acyl-CoA producing enzymes are also delivered to the nucleus suggests that high concentrations of metabolites generated loc...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040979 | Pride
Mediator  pyruvate dehydrogenase  2-ketoacid dehydrogenases  acetylation  chromatin  transcription 
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
ProteomicsA p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
Chromosomal instability (CIN) generates micronuclei, aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse, exposing DNA to the cytoplas...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD052675 | Pride
Chromosome missegregation Micronuclei P62 
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